基于3.0T MR及MIMICS对阿尔茨海默病患者侧脑室的研究

目的 比较分析阿尔茨海默病(AD)患者与正常老龄人侧脑室容积及形态,实现间接对AD患者脑实质萎缩进行评估.方法 运用3.0T MR对20例AD患者及20例正常老龄人进行头颅扫描,获得侧脑室切面图,测量侧脑室容积及侧脑室前角、后角及颞角,并运用比利时MIMICS软件对切面图像进行重建分析.结果 与正常老龄人侧脑室容积相比,AD组左侧脑室容积(LV)、右侧脑室容积(RV)及整体容积(TV)均明显增大,差异有统计学意义(P<0.05);与正常老龄人侧脑室前后角及颞角相比,AD组双侧前角及颞角度数显著增大,差异有统计学意义(P<0.05);AD组患者LV、RV、TV、左侧脑室前角、右侧脑室前角、左侧脑室颞角及右侧脑室颞角均与认知功能评定简易智能状态检查表(MMSE)呈负相关且有统计学意义(P<0.05).结论 AD患者侧脑室容积及角度均显著大于正常老龄人,相关测量数据可更为便捷准确提示AD患者脑实质萎缩状况.

Study of the lateral ventricular in patients with Alzheimer's disease at 3.0T MR and MIMICS reconstruction

Objective To evaluate cerebral parenchymal atrophy of patients with Alzheimer's disease(AD)through the compara-tive analysis of the volume and morphology of the brain ventricle between patients with AD and normal elderly.Methods 20 patients with AD and 20 normal elderly people were scanned at 3.0T MR,and lateral ventricle section images were achieved,and the lateral ventricle volume and the anterior horn,posterior horn and temporal horn of the lateral ventricle were calculated by analyzing the re-construction of section images with MIMICS software from Belgian.Results As compared with normal elderly group,the patients with AD exhibited significantly increased the volume of left ventricular volume(LV),right ventricular volume (RV)and total vol-ume (TV)(P<0.05).Angle of bilateral anterior horn and temporal horn but not posterior horn of the lateral ventricle in patients with AD were significantly higher than that in normal elderly (P<0.05).The volume of the left,right and total cerebral ventricle, the angle of the anterior horn of the left and right lateral ventricle and the angle of the temporal horn of the left and right lateral ven-tricle were negatively correlated with MMSE (P<0.05).Conclusion Patients with AD exhibites significantly greater volume and an-gle of the lateral ventricular than normal elderly people.These related data measured can predict brain parenchymal atrophy of pa-tients with AD more conveniently and accurately.