单、双指数模型DWI评价胃癌血管内皮生长因子的价值

目的 研究MR单指数扩散加权成像(DWI)表观扩散系数(ADC)值及双指数DWI真实扩散系数(D)值、相关扩散系数(D*)值、灌注分数(f)值对血管内皮生长因子(VEGF)表达水平的评价价值.方法 采用免疫组织化学染色方法检测28例胃癌组织切片及周围正常胃壁的VEGF表达并进行分级,分别分析ADC值、D值、D*值、f值在不同VEGF表达组间及胃癌不同分级间的差异.结果 不同VEGF分级间的ADC值、D值、f值差异有统计学意义,VEGF分级越高ADC值、D值越低,f值越高;高低分化胃癌的ADC值、D值、f值差异有统计学意义(P<0.05).结论 单指数模型DWI ADC值、双指数模型DWI D值、f值对评价胃癌VEGF表达有价值,可以反映胃癌血管生成.

The value of diffusion weighted imaging based on mono-exponential and bi-exponential model in evaluating the expression of vascular endothelial growth factor

Objective To evaluate the apparent diffusion coefficient(ADC) value of mono-exponential diffusion weighted imaging(DWI) and the true diffusion coefficient(D) value, related diffusion coefficient(D*) value, perfusion fraction (f) value of bi-exponential model DWI in reflecting the expression of vascular endothelial growth factor (VEGF).Methods Using immunohistochemical staining method to detect VEGF expression in the 28 cases of gastric carcinoma tissue section and the surrounding normal gastric tissue.The differences of ADC value, D value, D* value, f value in different VEGF expression grading and gastric carcinoma classification were analyzed respectively.Results The differences of ADC value, D value, f value between different VEGF grading were statically significant,as the higher VEGF grading accompanied wth the lower ADC values, D value and the higher of f value;and the differences of the parameters between high and low differentiated gastric carcinoma were also statically significant (P<0.05).Conclusion The ADC value of mono-exponential DWI and the D value,f value of bi-exponential model DWI could evaluate the expression of VEGF and reflect the gastric carcinoma angiogenesis.