亚急性期脑桥梗死脑默认网络的静息态fMRI研究

目的 探讨亚急性期脑桥梗死后脑默认网络(DMN)连接是否异常及可能的代偿机制.方法 23例亚急性脑桥梗死患者与23例年龄、受教育程度相匹配的健康受试者参加了本研究.在Philips Achieva 3.0T MRI上采集所有被试者静息态功能磁共振成像(rs-fMRI)数据.以后扣带回(PCC)为种子点,分别提取脑桥梗死组与对照组的DMN,分析相关脑区的功能连接(FC)情况.组间采用双样本t检验进行统计学分析.结果 与正常组相比,亚急性期脑桥梗死组FC增强的脑区包括:右侧中央后回、左侧内侧前额叶和左侧楔叶;FC减弱的脑区包括:双侧岛叶、左侧小脑后叶、右侧海马旁回、左侧枕下回.结论 亚急性期脑桥梗死患者的 DMN存在异常,FC的变化提示相关脑区皮质功能重组或代偿.

Study of the default mode network alteration after subacute pontine infarction using rs-fMRI

Objective To investigate the alteration and possible compensation mechanism of the default mode network (DMN) in patients with subacute pontine infarction.Methods Rs-fMRI data were collected from 23 patients with subacute pontine infarction and 23 normal controls.The data was analyzed with the functional connectivity (FC) method and compared between subacute pontine infarction patients and controls.All imaging was performed on a Philips Achieva 3.0T MRI scanner.Posterior cingulated cortox (PCC) was used as seed points to analyze the FC changes in the brain regions between the pontine infarction group and the controls.The discrepancies of experiment data between two groups were compared by using two-sample t-test analysis.Results The FC of the DMN showed a significant increase in the right postcentral gyrus, left medial prefrontal cortex and left precuneus compared with normal controls and a significant decrease in bilateral insula,posterior lobe of the left cerebellum,right parahippocampal gyrus and left inferior occipital gyrus.Conclusion The DMN altered in patients with subacute pontine infarction and the changes of the FC suggested the plasticity of cortical or compensation in the relevant brain areas.