卵巢早衰31例临床分析及治疗探讨

目的:总结卵巢早衰的临床资料,探讨卵巢早衰的治疗。方法:对1999年1月至2003年12月31例卵巢早衰患者的临床资料进行分析。结果:月经初潮平均年龄为13.4岁,继发闭经的妇女在停经前平均行经8.2年,闭经期限平均为2.8年(5个月至7年),其中突然闭经者7人,月经稀少渐至闭经者24人;16例(51.6%)的患者有低雌激素血症的表现,15例(48.4%)有程度不等的生殖器萎缩及乳房萎缩;血清性激素测定显示:雌二醇值明显低于或等于卵泡期水平,促卵泡素和促黄体生成素值升高及催乳素值在正常范围;全部患者给予人工周期治疗,治愈率为22.6%,有效率为25.8%,但无1例妊娠。结论:卵巢早衰是一种多因素引起的疾病,治疗困难,值得重视和研究。

Clinical analysis and treatment investigation of 31 premature ovarian failure

Objective: To summarize the clinical data and investigate the treatment of patients with premature ovarian failure.Methods: Thirty-one patients with premature ovarian failure were evaluated from January 1999 to December 2003. Results: Among 31 cases, there were 22 infertile patients and 9 patients with fertility. The average period of amenorrhea was 2.8 years(from 5 months to 7 years), in which there were 7 cases with the abrupt cessation of menstruation and 24 patients with oligomenorrhea and gradually to cessation of menstruation. 16 patients had the symptoms of estrogen deficiency and 48.4% of patients had genital and breast atrophy at different rates. The circulating concentration of estradiol was reduced and follicle-stimulating hormone and luteinizing hormone levels increased. All patients were treated with a combination of estrogen and progesterone. The cure rate of premature ovarian failure was 22.6% and no patient was treated to have a pregnancy. Conclusion: Premature ovarian failure is a disease of multifactors. Further study and emphasis ought to be taken to investigate it.