广州地区女性HPV感染及分型影响因素分析

目的 了解广东省广州中山大学附属第三医院门诊就诊妇女宫颈人乳头瘤病毒(HPV)感染及基因型情况,探讨HPV感染的高危因素.方法 选取2010年3月1日-2011年1月31日到广州中山大学第三医院妇科就诊并接受HPV检查和问卷调查的360名妇女,利用核酸分子杂交基因芯片技术检测21种HPVDNA.结果 HPV感染138例,感染率为38.3%,检出高危型15种,低危型4种;感染率最高的亚型为HPV16型共55例,占15.3%,其余依次为HPV58型33例,占9.2%,HPV52型19例,占5.3%;不同年龄HPV感染率差异无统计学意义(P>0.05);单因素分析结果表明,初次性生活年龄、伴侣吸烟、性伴侣数、伴侣的性伴数、避孕方式是HPV感染的影响因素(P<0.05);多因素分析结果显示,初次性生活年龄过小(≤19岁)(P=0.002)、,配偶的多性伴侣(≥2个)(P=0.001)为影响HPV感染的独立危险因素.结论 广州中山三院门诊妇女HPV感染常见的亚型依次为HPV16、58、52型,初次性生活的年龄过小、配偶的多性伴为HPV感染的独立高危因素.

Risk factors and genotype of HPV infection among women in Guangzhou city

Objective To investigate risk factors and genotype of human papilloma virus(HPV) among female outpatients in Guangzhou city.Methods The female outpatients visiting the Third Affiliated Hospital of Sun Yat-sen University and receiving HPV test were selected from March 2010 through January 2011.A total of 360 female outpatients were checked for 21 HPV DNA types with DNA flow-though hybridization genotyping technique and a questionnaire survey was conducted among the women.Results The HPV infection rate in the women was 38.3%.Totally 19 types of HPV were identified including strains of 15 HPV-H and 4 HPV-L.HPV42 and HPV43 were not detected.HPV16,58,52,33 were the most prevalent high-risk subtypes.Low risk type HPVcp8304 was prevalent.The total infection rate of HPV18,6,11 was 2.5%.High-risk types were more frequently found in the outpatiens,with a infection rate of 34.4%.The infection rate of low-risk subtypes was 6.4% and the rate of multiple infection was 8.3%.No correlation between HPV infection and age was observed.The results of logistic regression showed that early age at first sexual intercourse(≤19 years old) and more than one sexual partner of the spouse were the independent risk factors of HPV infection.Conclusion HPV16,58,52 are the most prevalent high-risk subtypes and early age at first sexual intercourse and more than one sexual partner of the spouse are the independent risk factors of HPV infection among women in Guangzhou city.