孕三烯酮用于紧急避孕120例临床观察

目的 :对孕三烯酮 ( R2 3 2 3 )的紧急避孕效果、副反应及对下次月经的影响进行前瞻性临床观察。方法 :1 2 0名要求紧急避孕的妇女 ,单次口服 5mg R2 3 2 3后进行随访 ,观察用药后的副反应和月经情况 ,按 Dixon法推算其避孕有效率。结果 :1 2 0名受试者的总预期妊娠数为 9.0 1 4,实际妊娠 1例 ,避孕有效率为 88.9% ,失败率为 0 .83 %。 1 0 %的受试妇女有轻微头痛、腹痛、恶心、呕吐等副反应 ,无需特殊处理。对下次月经无明显影响。结论 :5mg R2 3 2 3用于紧急避孕时安全有效 ,剂量小 ,副反应少 ,对月经周期无明显干扰。尚有待于大样本多中心研究证实

Effects of Gestrinone (R2323) on emergency contraception:a clinical observation of 120 cases

Objective: The efficacy, side effects and the effect on the following menstruation of gestrinone (R2323) used as an emergency contraceptive were prospectively observed. Methods: 120 heath women who need emergency contraception were recruited and treated with gestrinone in a single dose of 5 mg. The efficacy rate of contraception was estimated according to Dixon method. Side effects and the following menstruation were followed-up at out-patient clinic. Results: The total number of expected pregnancy was 9.014 according to the Dixon's method, actually there was one pregnancy occurred. The efficacy rate was 88.9% in the prevention of unplanned pregnancy, the failure rate was 0.83%. The side effects occurred in about 10% cases, such as headache, abdominal pain, nausea, vomiting etc., moreover they were very mild and no medication was needed. There was no significant disturbance on following menstrual pattern. Conclusions: Single dose of 5 mg gestrinone could be used clinically as a new effective emergency contraceptive. Of course, this conclusion here needs a further confirm in the near future, for example, a multicentre clinical trial of 5 mg R2323 compared randomly with other emergency contraceptive methods.