曲唑酮与地西泮治疗焦虑性神经症的疗效对照研究

目的 评价曲唑酮治疗焦虑性神经症的疗效和副反应。方法 对５６例焦虑性神经症患者，采用曲唑酮（２８例）地西泮（２８例）进行对照治疗（疗程４例）。采用副反应量表（ＴＥＳＳ）和焦虑自评量表（ＳＡＳ）、焦虑量表（ＨＡＤＭ）评定疗效和副反应。结果 曲唑酮与地西泮的疗效相近（Ｐ〉０．０５）。治疗第４周末ＳＡＳ、ＨＡＭＡ及ＨＡＭＡ因子分的减分率两组差异有非常显著性（Ｐ〈０．０１）。副反应两药相似。曲唑酮的主要副反应为困倦和嗜睡。结论 曲唑酮治疗焦虑性神经症有效，副反应轻微。

A controlled study between trazodone and dixipan in the treatment of anxiety neurosis.

Objective The aim of this study was to investigate the efficiency and safety of nemonapride in the treatment of anxiety neurosis.Methods A total of 56 patients who met CCMD-2-R criteria for anxiety neurosis were randomly assigned to treatment with trazodone( n =28) or dixipan( n =28)for four weeks.The efficiency was measured with the SAS and HAMA.The adverse events were determined by the treatment emergent symptons scale(TESS).Results There was no significant difference between two groups in overall response rate showed by the reduction rate of HAMA and SAS total scores.The overall incidence and presentations of the adverse events were comparable between two groups.The most commonly observed treatment emergent adverse events of the patients with trazodone treatment were sleepy and lethargy.Conclusions It is suggested that trazodone is safe and effective in the management of anxiety neurosis.