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Blood pressure modulation by substance P in the rat nucleus tractus solitarius
Authors:Takao Kubo  Minoru Kihara
Institution:1. Unidad de Gestión Clínica de Salud Mental, Instituto de Investigación Biomédica de Málaga-IBIMA, Hospital Regional Universitario de Málaga, Universidad de Málaga, Málaga, Spain;2. Grup de Recerca en Farmacologia Integrada i Neurociència de Sistemes, Programa de Recerca en Neurociéncia, Institut Hospital del Mar d''Investigacions Mèdiques-IMIM, Barcelona, Spain;3. Departament de Farmacologia, Toxicologia i Terapèutica, Facultat de Medicina, Universitat Autònoma de Barcelona, Barcelona, Spain;4. Departament de Ciéncies Experimentals i de la Salut Toxicologia, Facultat de Ciències de la Salut i de la Vida, Universitat Pompeu Fabra-UPF, Barcelona, Spain;5. Unidad de Gestión Clínica del Corazón, Instituto de Investigación Biomédica de Málaga-IBIMA, Hospital Universitario Virgen de la Victoria, Málaga, Spain;6. Centro de Investigación Biomédica en Red de Enfermedades Cardiovasculares (CIBERCV), Instituto de Salud Carlos III, Madrid, Spain;1. Department of Pediatrics, Children''s Hospital of Philadelphia, Philadelphia, PA, USA;2. Center for Pediatric Clinical Effectiveness, Children''s Hospital of Philadelphia, Philadelphia, PA, USA;3. Department of Biostatistics and Epidemiology, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA;4. Department of Pediatrics, Hospital for Sick Children, Toronto, Ontario, Canada;5. SickKids Research Institute, Hospital for Sick Children, Toronto, Ontario, Canada;6. Department of Medicine, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA
Abstract:Substance P in a dose of 0.1-10 ng injected into the nucleus tractus solitarii (NTS) of the rat caused hypotension, bradycardia and apnea whereas a dose of 100 ng led to no response. A substance P antagonist injected into the NTS abolished the cardiovascular responses to substance P. The antagonist alone increased blood pressure and heart rate. The data suggest a role for substance P in the cardiovascular regulation by the NTS.
Keywords:Substance P  Nucleus tractus solitarius  Substance P antagonist  Blood pressure  Heart rate  Rat
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