呋喃唑酮和一些常用抗溃疡药对四种大鼠胃溃疡模型的影响

呋喃唑酮在较小剂量(20～50mg/kg)即能对三种大鼠胃溃疡模型(慢性醋酸型,消炎痛型,幽门结扎型)显示明显的保护作用,对消炎痛模型的保护作用尤为突出。本药对应激型溃疡模型无效。已知的治疗消化性溃疡药物—生胃酮,阿托品、甲氰脒胍及多虑平并不显示上述作用特色。呋喃唑酮和生胃酮对幽门结扎模型的保护有协同作用。此外还对胃液进行了生化分析。

THE PROTECTIVE EFFECTS OF FURAZOLIDONE AND SOME COMMONLY USED ANTIULCER DRUGS ON SEVERAL GASTRIC ULCER MODELS IN RATS

Furazolidone in relatively small doses(i. e., 20～50 mg/kg) was found to be an effective anti-ulcer agent in three experimental gastric ulcer models in rats, namely, the acetic acid-induced chronic ulcer, indomethacin-induced and pyloric ligation induced ulcers. Among these, the indomethacin-induced ulcer was particularly markedly inhibited. In addition, a decrease of pepsin activity, an increase of hexosamine level and, in larger doses, a decrease of volume of gastric juice collected from pyloric-ligated stomaches were also observed. However, the drug was shown to be ineffective against the stress-restraint ulcer model.The above characteristic pattern of furazolidone action on various animal ulcer models was found not to be shared by known anti-ulcer drugs such as carbenoxolone, atropine, cimetidine and doxepin. Furazolidone and carbenoxolone showed synergistic effects on the pyloric ligation model. Therefore, it would be advisable to use a combination of subtherapeutic doses of both drugs in clinical gastric ulcer therapy, in expectation of obtaining better efficacy and fewer adverse effects.