Effector Cell Sensitivity to Sugar Moieties. I. Inhibition of Human Natural Killer Cell Activity by Monosaccharides |
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| Authors: | E.W. Ades Ann Hinson Janet M. Decker |
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| Affiliation: | 1. Department of Basic and Clinical Immunology and Microbiology, Medical University of South Carolina, Charleston, South Carolina, USA;2. Department of Biochemistry, Medical University of South Carolina, Charleston, South Carolina, USA |
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| Abstract: | Human natural killer (NK) cells recognize multiple target antigens. The ligands (antigens) involved in the effector-target cell interaction have not been extensively identified. In the present study, assays of NK activity in the presence of a panel of monosaccharides demonstrated inhibition of cytolysis in a dose-response fashion. We propose that NK cell activity involves the recognition of carbohydrate structures on target cells via receptors on the effector cell surface. |
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