| 气体信号分子硫化氢与缺血再灌注损伤 |
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| 引用本文： | 王新宝. 气体信号分子硫化氢与缺血再灌注损伤[J]. 首都医科大学学报, 2012, 33(1): 130-135. DOI: 10.3969/j.issn.1006-7795.2012.01.028 |
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| 作者姓名： | 王新宝 |
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| 作者单位： | 首都医科大学附属北京友谊医院儿科, 北京 100050 |
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| 摘 要： | 气体分子硫化氢(H2S)是近年来发现的第3种气体信号分子,在机体中发挥着重要的生物学作用,H2S可以明显减轻心脏、肺、肝脏、肾脏和小肠的缺血再灌注损伤,其机制与开放ATP敏感性钾、减少自由基的生成,抑制细胞凋亡和炎性反应有关,本文就H2S对缺血再灌注的作用及机制进行了综述
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| 关 键 词： | 气体信号分子 硫化氢 缺血再灌注 |
| 收稿时间： | 2011-08-29 |
Gasotransmitter hydrogen sulfide and ischemic reperfusion |
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| WANG Xin-bao. Gasotransmitter hydrogen sulfide and ischemic reperfusion[J]. Journal of Capital Medical University, 2012, 33(1): 130-135. DOI: 10.3969/j.issn.1006-7795.2012.01.028 |
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| Authors: | WANG Xin-bao |
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| Affiliation: | Department of Pediatrics, Beijing Friendship Hospital, Capital Medical University, Beijing 100050, China |
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| Abstract: | Recently hydrogen sulfide (H2S) is considered the third gasotransmitter and exerts important biological effects in mammals. Studies found that H2S could reduce ischemia reperfusion injury in heart, lung, liver, kidney and intestine. The mechanisms were related to opening of ATP sensitive kalium channel, reducing free radical formation, and inhibiting cell apoptosis and inflammation. The present article reviewed the effect and mechanisms of H2S on ischemic reperfusion. |
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| Keywords: | gasotransmitter hydrogen sulfide ischemic reperfusion |
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