| 失血性休克的大鼠肠系膜动脉节律基因表达的变化 |
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| 引用本文： | 张惠琴,谢一舟,田国华,刘延友,汪宇辉,江舟,王正荣.失血性休克的大鼠肠系膜动脉节律基因表达的变化[J].四川生理科学杂志,2011,33(2):51-52. |
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| 作者姓名： | 张惠琴 谢一舟 田国华 刘延友 汪宇辉 江舟 王正荣 |
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| 作者单位： | 卫生部时间生物学重点实验室,四川大学华西医学中心,四川,成都,610041 |
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| 基金项目： | 国家自然科学基金资助课题 |
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| 摘 要： | 目的:建立失血性休克大鼠模型及探讨失血性休克大鼠肠系膜上动脉(SMA)节律基因表达的变化。方法:建立失血性休克大鼠模型并随机分为失血性休克组和空白对照组,通过RT-PCR检测模型肠系膜上动脉节律基因per1、per2 mRNA的表达水平。结果:休克组与对照组相比,前者肠系膜上动脉节律基因per1、per2的mRNA表达降低(p<0.05)。结论:失血性休克模型肠系膜上动脉节律基因per1、per2表达水平下调,提示失血性休克可以影响节律基因的表达。
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| 关 键 词： | 失血性休克 肠系膜上动脉 节律基因 |
Changes of circadian gene expressions in superior mesenteric artery of rats after hemorrhagic shock |
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| Zhang Hui-qin,Xie Yi-zhou,Tian Guo-hua,Liu Yan-you,Wang Yu-hui,Jiang Zhou,Wang Zheng-rong.Changes of circadian gene expressions in superior mesenteric artery of rats after hemorrhagic shock[J].Sichuan Journal of Physiological Sciences,2011,33(2):51-52. |
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| Authors: | Zhang Hui-qin Xie Yi-zhou Tian Guo-hua Liu Yan-you Wang Yu-hui Jiang Zhou Wang Zheng-rong |
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| Institution: | Zhang Hui-qin,Xie Yi-zhou,Tian Guo-hua,Liu Yan-you,Wang Yu-hui,Jiang Zhou,Wang Zheng-rong(Key Laboratory of Chronobiology,Ministry of Health,State Key Laboratory of Biotherapy,Sichuan University,Sichuan Chengdu 610041) |
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| Abstract: | Objective: To establish the rat model of hemorrhagic shock and to explore the changes of per1 and per2 gene expressions in superior mesenteric artery of rats after hemorrhagic shock.Methods: The rat model of hemorrhagic shock is established.The hemorrhagic shock group and control group were set.The per1 and per2 mRNA expression of SMA were measured by RT-PCR.Results: The level of per1 and per2 mRNA in shock group is lower than in the control group(p<0.05),Conclusion: The per1 and per2 gene expressions in SM... |
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| Keywords: | Hemorrhagic shock Gene expression Superior mesenteric artery |
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