| N末端脑利钠肽原是左心室功能正常的稳定性心绞痛患者冠状动脉病变进展的预测标志物 |
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| 引用本文： | 徐延路,郑欣馨,朱成刚,郭远林,郑昕,滕思勇,高展,慕朝伟,袁晋青,李建军. N末端脑利钠肽原是左心室功能正常的稳定性心绞痛患者冠状动脉病变进展的预测标志物[J]. 中国分子心脏病学杂志, 2011, 11(1) |
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| 作者姓名： | 徐延路 郑欣馨 朱成刚 郭远林 郑昕 滕思勇 高展 慕朝伟 袁晋青 李建军 |
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| 作者单位： | 北京协和医学院中国医学科学院阜外心血管病医院心内科北京市西城区北礼士路167号,100037 |
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| 基金项目： | 阜外心血管病医院博士生培养基金，国家自然科学基金，北京市自然科学基金((No.7082081).教育部博士点基金 |
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| 摘 要： | 目的探讨N-末端脑利钠钛原(NT-proBNP)对冠状动脉病变进展和支架内再狭窄的预测价值。方法测定303例左心室收缩功能(射血分数>50%)正常的慢性稳定性心绞痛患者入院时及随访时的血浆NT-proBNP浓度。所有患者于支架植入术后6-9个月行造影随访。结果进展组患者入院时NT-proBNP浓度高于非进展组患者(455fmol/ml vs431fmol/ml,P=0.017)。多元回归分析显示入院时血浆NT-proBNP可独立预测冠状动脉非靶病变造影显示的快速进展(OR=1.944,95%CI1.047-3.608,P=0.035)。NT-proBNP水平与靶病变支架内再狭窄无关。结论入院时血浆NT-proBNP是左心室功能正常的稳定性心绞痛患者冠状动脉病变进展而非再狭窄的独立预测因子。
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| 关 键 词： | N末端脑利钠钛原 稳定性心绞痛 动脉造影术 支架内再狭窄 |
N-terminal pro-brain natriuretic peptide predicts angiographic progression of subclinical atherosclerotic disease in patients with stable angina and preserved left ventricular function |
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| XU Yan-Lu,ZHENG Xin-Xin,ZHU Cheng-Gang,GUO Yuan-Lin,ZHENG Xin,TEN Si-Yong,GAO Zhan,MU Chao-Wei,YUAN Jin-Qing,LI Jian-Jun. N-terminal pro-brain natriuretic peptide predicts angiographic progression of subclinical atherosclerotic disease in patients with stable angina and preserved left ventricular function[J]. Molecular Cardiology of China, 2011, 11(1) |
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| Authors: | XU Yan-Lu ZHENG Xin-Xin ZHU Cheng-Gang GUO Yuan-Lin ZHENG Xin TEN Si-Yong GAO Zhan MU Chao-Wei YUAN Jin-Qing LI Jian-Jun |
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| Affiliation: | XU Yan-Lu; ZHENG Xin-Xin; ZHU Cheng-Gang; GUO Yuan-Lin; ZHENG Xin; TEN Si-Yong; GAO Zhan; MU Chao-Wei; YUAN Jin-Qing; LI Jian-Jun .Department of Cardiology; Fu Wai Hospital; Chinese Academy of Medical Sciences & Peking Union Medical College; BeiLiShi Road 167; Beijing 100037; China; |
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| Abstract: | Objective N-terminal pro-brain natriuretic peptide (NT-proBNP) has been a strong prognostic biomarker regarding cardiovascular mortality for patients with chronic stable angina pectoris (CSA) treated with coronary stenting. However, its ability to predict angiographic adverse outcomes such as atherosclerosis progression and in-stent restenosis (ISR) remains unclear. We tested whether NT-proBNP could predict rapid angiographic progression (RAP) of non-target coronary artery atherosclerosis (NCAA) as well as ... |
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| Keywords: | N-Terminal Pro-Brain Natriuretic Peptide Stable Angina Angiography In-Stent Restenosis |
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