| 同源异型盒基因CDX1和CDX2使食管腺癌细胞恶性降低 |
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| 引用本文： | 马丽萍,李娜,潘秀英,董建强,陈晓欣.同源异型盒基因CDX1和CDX2使食管腺癌细胞恶性降低[J].基础医学与临床,2006,26(12):1319-1323. |
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| 作者姓名： | 马丽萍 李娜 潘秀英 董建强 陈晓欣 |
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| 作者单位： | 北京大学,人民医院,中心实验室,北京,100044;北京大学,人民医院,中心实验室,北京,100044;北京大学,人民医院,中心实验室,北京,100044;北京大学,人民医院,中心实验室,北京,100044;北京大学,人民医院,中心实验室,北京,100044 |
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| 基金项目： | 国家自然科学基金(30171050) |
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| 摘 要： | 目的探讨同源异型盒基因CDX1和CDX2对食管腺癌细胞表型的影响。方法用携带人CDX1或CDX2的表达载体转染食管腺癌细胞系SEG-1,观察形态、生长率变化、分裂指数、致瘤性等。结果CDX1或CDX2单独作用都使SEG-1出现类腺样生长排列、生长率下降、分裂指数降低、致瘤性减弱,CDX2的作用大于CDX1。结论CDX1和CDX2均能促进食管腺癌细胞SEG-1分化,减低其恶性。
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| 关 键 词： | CDX1 CDX2 食管腺癌 SEG-1 |
| 文章编号： | 1001-6325(2006)12-1319-05 |
| 收稿时间： | 2006-05-30 |
| 修稿时间： | 2006-09-21 |
Homeobox genes CDX1 and CDX2 reduced malignancy of esophageal adenocarcinoma cells |
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| MA Li-ping,LI Na,PAN Xiu-ying,DONG Jian-qiang,CHEN Xiao-xin.Homeobox genes CDX1 and CDX2 reduced malignancy of esophageal adenocarcinoma cells[J].Basic Medical Sciences and Clinics,2006,26(12):1319-1323. |
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| Authors: | MA Li-ping LI Na PAN Xiu-ying DONG Jian-qiang CHEN Xiao-xin |
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| Abstract: | Objective To study the effect of homeobox genes CDX1 and CDX2 on the phenotype of esophageal adenocarcinoma cells.Methods Esophageal adenocarcinoma cell line SEG-1 was transfected with CDX1 or CDX2 cDNA.The morphology,growth rate,division index and tumorigenicity were analyzed.Results The expression of CDX1 or CDX2 leaded to occurring adeniform-like manifestation.The growth rate,division index and tumorigenicity were reduced,especially by CDX2.Conclusion CDX1 and CDX2 all could increase differentiation of esophageal adenocarcinoma cells and reduction of its malignancy. |
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| Keywords: | CDX1 CDX2 esophageal adenocarcinoma cell SEG-1 |
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