Convulsion in two non-epileptic patients following induction of anesthesia with propofol

Two non-epileptic patients developed convulsions immediately after induction of anesthesia with propofol. Their vital signs were stable during operation and they recovered from convulsion promptly. Case 1: A 25-year-old man was scheduled for lumbar herniectomy. Anesthesia was induced with propofol 200 mg (2 mg.kg-1). On termination of propofol administration, he developed generalized shivering like movements. Although tracheal intubation was performed with suxamethonium 100 mg, he showed no fasciculations. Vital signs and Spo2 were stable except increase of pulse rate from 70 to 116.min-1 for a few minutes. Case 2: A 75-year-old female was scheduled for cholecystectomy for cholelithiasis. Immediately after induction with propofol 60 mg (1.5 mg.kg-1), she developed generalized tonic-clonic convulsion, and she had her trachea intubated with aid of vecuronium 6 mg. Propofol-related convulsion may occur in non-epileptic patients.