B型尿钠肽对ST-AMI溶栓治疗的临床价值

目的观察急性ST-T抬高的心肌梗死（ST-AM I）溶栓治疗的患者其B型尿钠肽（BNP）水平变化及其临床价值。方法监测ST-T抬高的急性心肌梗死患者溶栓前后的BNP水平及心肌酶学等改变 并于溶栓后1周左右时行冠脉造影检查,进行TIM I分级,比较其BNP及心肌酶学的水平,将同期诊断为冠心病心绞痛患者做为对照组。结果实验组的BNP水平显著高于对照组,实验组溶栓再通者的BNP水平下降较未再通组明显（P〈0.01）。结论BNP是反应心肌缺血坏死严重性的生物标志物,可以用来做为观察溶栓再通与否及疗效的指标。

B -type Natriuretic Peptide Level in Patients with ST- T Elevation Myocardial Infarction after Thrombolysis

Objective To evaluate plasma level of B - type natriuretic peptide of patients with ST - T elevation myocardial infaction （ ST - AMI） After thrombolysis. Methods We obtain the sample from 32 patients with ST - AMI before and after thrombolysis. 35 patients with stable angina were as control group. Results There were significant differences between study group and control group with BNP levels （451 ±218）pg/ml, （32 ± 11.5）pg/ml, P 〈0. 001]. The study group with TI- MI3 BNP level decrease were significantly lower than those of TIMI1 （ 105 ± 33 ） pg/ml, （ 321 ± 110） pg/ml, P 〈0.01] Conclusion The change of BNP levels indicate that they are involved in the severity and improvement of ST - AMI after thrombolysis, So BNP as a biomarker for physician are important to the treatment and prognosis.