| 辛伐他汀对冠心病患者PCI术后高敏C反应蛋白的影响 |
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| 引用本文： | 王小素,;温西京,;秦小飞. 辛伐他汀对冠心病患者PCI术后高敏C反应蛋白的影响[J]. 河南医药信息, 2009, 0(23): 31-32 |
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| 作者姓名： | 王小素, 温西京, 秦小飞 |
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| 作者单位： | [1]河南煤炭建设集团公司职工医院心内科,郑州市450009; [2]郑州大学第一附属医院心内科,郑州市450052 |
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| 摘 要： | 目的观察口服辛伐他汀对冠心病患者介入治疗后高敏C反应蛋白的影响。方法入选冠心病拟PC I治疗的患者74例,随机分为辛伐他汀组（n=37例）和对照组（n=37例）,辛伐他汀组患者术前在标准治疗基础上口服辛伐他汀40mg/d共1周,对照组除未服辛伐他汀外其他治疗均与辛伐他汀组相同,两组患者分别于术前、术后5天每天采集空腹静脉血3m l,对高敏C反应蛋白进行定量分析。结果PC I术后两组高敏C反应蛋白均显著升高（P〈0.05）,辛伐他汀组高敏C反应蛋白升高幅度显著低于对照组（P〈0.05）。结论冠心病患者PC I术前口服辛伐他汀可显著减低PC I术后高敏C反应蛋白的升高。
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| 关 键 词： | 辛伐他汀 高敏C反应蛋白 血管成形术 经皮 冠心病 |
Effects of Simvastatin on Blood hs - CRP Levels in Patients with CHD after Percutaneous Coronary Intervention |
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| Affiliation: | WANG Xiaosu, WEN Xijing , QIN Xiaofei (Staff Hospital of Henan Coal Construction Group Company, Zhengzhou 450009, China) |
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| Abstract: | Objective To investigate the effects of Simvastatin on blood levels of hs - CRP after percutaneous coronary intervention. Methods Seventy - fourh patients with CHD were enrolled in the study. Patients scheduled for elective coronary intervention were assigned to Simvastatin （40 mg/d, n = 37） or placebo （ n = 37） 7 days before the procedure according to in - hospital sequence. The hs -CRP levels were measured at baseline and at 1 st,2nd,4th,5th, 7th days after the procedure. ResuLts Detection of hs - CRP was significantly higher after the procedure compared with baseline. Conclusion Pretreatment with Simvastatin 40mg/d for 7 days significantly reduce postoperative hs - CRP in elective coronary intervention. |
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| Keywords: | Simvastatin hs - CRP Angioplasty Transluminal Coronary Heart Disease |
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