| 不同组合治疗类风湿关节炎对肝酶的影响 |
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| 引用本文： | 史丽璞,;和雅,;朱明慧,;刘旭华.不同组合治疗类风湿关节炎对肝酶的影响[J].河南医药信息,2009(24):1-3. |
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| 作者姓名： | 史丽璞 ;和雅 ;朱明慧 ;刘旭华 |
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| 作者单位： | [1]郑州人民医院风湿免疫科,郑州市450003; [2]郑州人民医院检验科,郑州市450003 |
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| 摘 要： | 目的研究不同组合治疗类风湿关节炎（RA）对肝酶的影响。方法40例患者,随机分为两组：甲氨喋呤（MTX）＋来氟米特（LEF）组、甲氨喋呤（MTX）＋来氟米特（LEF）＋白芍总苷（TGP）组,每组20例。分别于治疗0、4、8、12周比较肝功。结果治疗第12周疗效比较：MTX＋LEF＋TGP组总有效率95%,明显优于MTX＋LEF组（有效率90%）。MTX＋LEF组的肝损害高于MTX＋LEF＋TGP组。肝损害多见于具有危险因素的患者,多发生于用药4周以后。结论联合应用TGP治疗活动期RA,近期疗效显著优于MTX＋LEF组;联合应用TGP后肝损害减少。
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| 关 键 词： | 类风湿关节炎 白芍总苷 肝酶 |
Effect of Different Combination on Transaminase in Treatment of Rheumatoid Arthritis |
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| Institution: | SHI Lipu, HE Ya, ZHU Minghui, et al( Department of Rheumatology and Immunology, Zhengzhou People＇ s Hospital, Zhengzhou 450003, China) |
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| Abstract: | Objective To investigate the effect of different combination on transaminase in the treatment of rheumatoid arthritis.Methods Total 40 patients were divided into 2 groups randomly,one is the MTX and LEF group,and the other is the MTX and LEF and TGP group with 20 patients.We measured the hepatic function every 4 weeks for three months.Results We found that the effective power of the MTX and LEF and TGP group was 95%,which is obviously higher than that of MTX and LEF group which the effective power is 90%. Patients of the MTX and LEF group experienced more hepatic more patic injury, which usually affected the ones with risk factors after 4 weeks treatment. Conclusion It is effective in the treatment of active RA combining TGP than the MTX and LEF group ,with less heinjury |
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| Keywords: | Rheumatoid arthritis Total Glucosides of Paeony Transaminase |
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