| 高剂量脂布福吉宁对豚鼠心肌的电药理学作用 |
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| 引用本文： | 李俊英,谢来华. 高剂量脂布福吉宁对豚鼠心肌的电药理学作用[J]. 中国药理学通报, 1994, 0(2) |
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| 作者姓名： | 李俊英 谢来华 |
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| 作者单位： | 南开大学物理系生物物理室 |
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| 摘 要： | 应用玻璃微电极记录心肌细胞的跨膜动作电位．研究脂布福吉宁（ＲＢＧ）对豚鼠心室肌的电药理学作用。结果表明；ＲＢＧ可使静息电位．动作电位振幅．动作电位时程．０相最大上升速率降低，并可诱发迟后去极化（ＤＡＤ）及触发性心律失常．产生的ＤＡＤ有快频率依赖性。ＲＢＧ的作用有剂量依赖性。
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| 关 键 词： | 豚鼠心室乳头肌，微电极，脂布福吉宁，触发性活动 |
The electropharmacological effects of high dose resibufogenin on guinea pig cardiac muscle |
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| LI Jun-Ying,XIE Lai-hua. The electropharmacological effects of high dose resibufogenin on guinea pig cardiac muscle[J]. Chinese Pharmacological Bulletin, 1994, 0(2) |
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| Authors: | LI Jun-Ying XIE Lai-hua |
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| Abstract: | Electropharmacological effects of resibufogenin(RBG)on guinea pig papillary muscle were studied by means of conventional glass microelectrode technique.The results were follows:After treated with RBG,the resting potential(RP),action potential amplitude(APA),action potential duration(APD) and Vmax decreased,Delayed afterdepolarization (DAD)and triggered arrhytnmias were induced.The amplitude and coupling interval of DADs depended on the basic cycle length(BCL) of the stimulation, The effects of RBG on the membrance potential of papillary muscle were concentration-dependent. |
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| Keywords: | guinea pig papillary muscle microelectrode resibufogenin triggered activity |
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