吗啡在持续硬膜外与静脉镇痛效应相同时血浆浓度差异

目的研究术后镇痛药吗啡通过不同给药方式的临床用药剂量与血药浓度的关系及吗啡PCIA用药剂量的最佳效果与安全性。方法通过对60例腹部手术后患者术后镇痛（PCA）的对比研究，探索术后患者持续静脉镇痛（PCIA）与持续硬膜外镇痛（PCEA）的用药剂量差别、血药浓度差别、副作用的防治。结果PCIA组与PCEA组均达满意镇痛，未出现严重副作用，未出现成癌性。在VAs评分接近时，PCIA组吗啡血药浓度明显高于PCEA组。结论吗啡在持续静脉与硬膜外镇痛效应相同时血浆吗啡浓度差异明显，吗啡在短期行PCIA或PCEA均安全有效，药物成癌发生的可能性小。

Relationship between plasma concentration and dosage of morphine PCIA through different drug delivery dosage

Objective To study drug morphine postoperative analgesia through different drug delivery dosage forms of the clinical and the relationship between plasma concentration and dosage of morphine PCIA the best results and safety. Methods 60 cases of abdominal surgery in patients with postop-erative analgesia （PCA） of the comparative study to explore patients with sustained postoperative intravenous analgesia （PCIA） and continuous epidural analgesia （PCEA） of the difference between dosage, plasma concentration differences in the prevention and treatment side effects. Results Each group satisfied with the pain, no serious side effects,no addiction. When the VAS score close,PCIA morphine group was significantly higher than plasma concentration PCEA group. Conclusions Continuous intravenous morphine in the epidural analgesia with the same effect of differences in plasma concentrations of morphine,morphine PCIA line in the short term or PCEA are safe and effective,the possibility of occurrence of drug addiction small.