岩藻聚糖硫酸酯对血小板黏附和聚集的影响

目的研究褐藻中岩藻聚糖硫酸酯对血小板黏附和聚集的影响。方法将20只新西兰白兔随机分为2组：岩藻聚糖硫酸酯组和空白对照组,分别进行血小板黏附试验（PAdT）、血小板聚集试验（PAgT）和血栓素B2（TXB2）测定。结果岩藻聚糖硫酸酯组和空白对照组血小板黏附试验的黏附率测定分别为16.7±6.3%、32.6±9.5%,P〈0.05,差别有显著意义;血小板聚集试验的最大聚集率测定分别为56.2±7.8（S）、78.4±10.7（S）,P〈0.05,差别有显著意义;血栓素B2测定分别为16.2±3.8ng/L、123.6±41.3ng/L,P〈0.05,差别有显著意义。结论岩藻聚糖硫酸酯抑制血小板的黏附与聚集。

The Effect of Fucoidan from Brown Seaweeds on the Adhesion and Aggregation of Platelet

Objective To study the effect of Fucoidan from Brown Seaweeds on the adhesion and aggregation of platelet.Methods Twenty New Zealand rabbits were randomized into two groups：the Fucoidan group and the control group.PAdT、PAgT and TXB2 of the two groups were separately examined.Results PAdT、PAgT and TXB2 in the Fucoidan group were separately 16.7±6.3%、56.2±7.8（S）、16.2±3.8ng/L and the control group were separately 32.6±9.5%、78.4±10.7（S）、123.6±41.3ng/L.P〈0.05,There were statistically significance between two groups.Conclusions The Fucoidan from Brown Seaweeds inhibits the adhesion and aggregation of platelet.