| MMP-2和MMP-9在乳腺癌中的表达及其意义 |
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| 引用本文： | 谢伟,冯茂辉,王维娜,袁宏银,胡名柏,程伏林,龚玲玲.MMP-2和MMP-9在乳腺癌中的表达及其意义[J].武汉大学学报(医学版),2003,24(4):341-342,355. |
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| 作者姓名： | 谢伟 冯茂辉 王维娜 袁宏银 胡名柏 程伏林 龚玲玲 |
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| 作者单位： | 1. 武汉大学中南医院肿瘤科,武汉,430071
2. 黄石市卫校,黄石,435001 |
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| 摘 要： | 目的 :探讨基质金属蛋白酶 2、 9(MMP 2、MMP 9)在乳腺良性病变及乳腺癌组织中的表达及意义。方法 :应用免疫组化SP法检测 12例乳腺良性病变及 32例乳腺癌组织中MMP 2和MMP 9的表达。结果 :MMP 2和MMP 9在乳腺癌中的表达明显高于乳腺良性组织 ,且乳腺癌患者中有淋巴结转移组MMP 2、MMP 9的表达明显高于无淋巴结转移组。结论 :MMP 2和MMP 9在乳腺癌组织中有高表达且在乳腺癌细胞突破基底膜向外扩散、转移中起着重要作用 ,参与了乳腺癌的转移过程
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| 关 键 词： | 乳腺良性病变 乳腺癌 基质金属蛋白酶 |
Expression of Matrixmetalloproteinase-2 and -9 and its Significance in Breast Carcinoma |
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| Xie Wei,Feng Maohui,Wang Weina,et al.Expression of Matrixmetalloproteinase-2 and -9 and its Significance in Breast Carcinoma[J].Medical Journal of Wuhan University,2003,24(4):341-342,355. |
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| Authors: | Xie Wei Feng Maohui Wang Weina |
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| Institution: | Xie Wei,Feng Maohui,Wang Weina,et al Department of Oncology,Zhongnan Hospital,Wuhan University,Wuhan 430071,China |
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| Abstract: | Objective: To study the expression of matrixmetalloproteinase(MMP) 2 and 9 and its significance in benign breast disease and breast carcinoma. Methods: Expression of MMP 2 and 9 was observed by SP immunohistochemical technique in 12 benign breast diseases and 32 breast carcinomas. Results: Expression of MMP 2 and 9 in breast cancer was much higher than that in benign breast disease(P<0.01). Compared with breast carcinomas without positive metastasis, expression of MMP 2 and 9 was upregulated in those with lymphnode metastasis(P<0.05). Conclusion: MMP 2 and 9 may play an important role in the invasion and metastasis of breast cancer. |
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| Keywords: | benign breast disease breast cancer matrixmetalloproteinase |
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