放射性肺炎影响因素的多元回归分析

目的探讨放射性肺炎发生的影响因素,以指导肺癌治疗计划的制定,避免和减少正常肺组织的放射损伤.方法选取101例放射性肺炎患者,研究照射剂量等20个因素与放射性肺炎的关系.应用SPSS*!8.0进行χ2检验的单因素分析、Logistic多元回归分析筛选影响因素.结果①单因素分析显示肺部感染、肺不张、阻塞性肺炎、胸水、心血管疾患、慢性支气管炎史、化疗史、照射剂量、照射天数、照射野大小10个因素与放射性肺炎的发生有关.②多因素研究发现肺部感染、阻塞性肺炎、肺不张、胸水、慢性支气管炎史、心血管疾患、化疗史、照射剂量、照射野大小9个因素为放射性肺炎发生的独立影响因素.结论在制定肺癌放射治疗计划时,充分考虑患者的合并症、化疗史、照射剂量、照射野大小等因素,可减少放射性肺炎的发生机会.

Logistic regression analysis on the risk factors of radiation pneumonitis

Objective To identify the risk factors of radiation pneumonitis(RP). Methods A retrospective study was conducted on 101 patients with radiation pneumonitis using SPSS?8.0 software. Factors evaluated included: gender, age, pathology, clinical stage, irradiation dose, irradiation field size, history of smoking, cardiovascular disease,bronchitis, surgery, chemotherapy ,lung infection ,atelactasis,obstructive infection and pleural effusion. Univariate analysis was performed using Chi-Square test and multivariate anal1ysis was performed using Logistic regression model. Results Univariate analysis revealed a significant relationship between 10 factors :pulmonary infection, atelectasis, obstructive infection,cardiovascular disease,bronchitis, chemotherapy,irradiation dose, number of days of radiation and irradiation field size were factors leading to radiation pneumonitis. Multivariate analysis showed that 9 factors:pulmonary infection, obstractive infection ,atelactasis, pleural effusion,bronchitis,cardiovascular disease, chemotherapy,irradiation dose, and irradiation field size were independent factors. Conclusion Comprehensive consideration of the accompanying disease,chemotherapy,dose,field size,etc during the planning of radiotherapy is able to minimize the possibility of developing radiation pneumonitis.