| STUDY OF ANTI-CD9 AND CD 10 IMMUNOTOXINS KILLING LEUKEMIC CELLS AND THE EFFECT ON HEMATOPOIESIS |
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| 引用本文： | 黎燕,贺永怀,陈兴,孙英勋,沈倍奋. STUDY OF ANTI-CD9 AND CD 10 IMMUNOTOXINS KILLING LEUKEMIC CELLS AND THE EFFECT ON HEMATOPOIESIS[J]. 中国癌症研究, 1991, 3(4): 13-17. DOI: 10.1007/BF02997271 |
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| 作者姓名： | 黎燕 贺永怀 陈兴 孙英勋 沈倍奋 |
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| 作者单位： | Institute of Basic Medical Sciences，Academy of Military Sciences，Beijing，Institute of Basic Medical Sciences，Academy of Military Sciences，Beijing，Institute of Basic Medical Sciences，Academy of Military Sciences，Beijing，Institute of Basic Medical Sciences，Academy of Military Sciences，Beijing，Institute of Basic Medical Sciences，Academy of Military Sciences，Beijing |
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| 摘 要： | Immuntoxins were synthesized by conjugating a plant toxic ricin with to three different monclonal antibodiesMoAb) directed against markers of human pre- B lymphocyte leukemic cells. It is useful to eliminate residual leukemic cells from bone marrow for preventing leukemia relapse after autologous bone marrow transplantation(ABMT). In the present work, the elimination of human leukemic cell line (Nalm-6) by three immunotoxins (anti-CD9 and anti-CD10) were observed. In addition, the proliferation of hematopoietic progenitors (CFU-GM. BFU E and CFU- mix) were not apparently inhibited by the immunotoxins in the range of effective concentrations. The possibility for utilizating immunotoxins in ABMT was discussed.
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Study of anti-CD9 and CD10 immunotoxins killing leukemic cells and the effect on hematopoiesis |
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| Yan Li,Yonghuai He,Xing Chen,Yingxun Sun,Beifen Shen. Study of anti-CD9 and CD10 immunotoxins killing leukemic cells and the effect on hematopoiesis[J]. Chinese Journal of Cancer Research, 1991, 3(4): 13-17. DOI: 10.1007/BF02997271 |
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| Authors: | Yan Li Yonghuai He Xing Chen Yingxun Sun Beifen Shen |
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| Affiliation: | 1. Institute of Basic Medical Sciences, Academy of Military Sciences, Beijing
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| Abstract: | Immuntoxins were synthesized by conjugating a plant toxic ricin with to three different monclonal antibodiesMoAb) directed against markers of human pre- B lymphocyte leukemic cells. It is useful to eliminate residual leukemic cells from bone marrow for preventing leukemia relapse after autologous bone marrow transplantation(ABMT). In the present work, the elimination of human leukemic cell line (Nalm-6) by three immunotoxins (anti-CD9 and anti-CD10) were observed. In addition, the proliferation of hematopoietic progenitors (CFU-GM. BFU E and CFU- mix) were not apparently inhibited by the immunotoxins in the range of effective concentrations. The possibility for utilizating immunotoxins in ABMT was discussed. |
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| Keywords: | immunotoxin. leukemia. |
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