A comparison of biochemical effects of nitrogen dioxide,ozone, and their combination in mouse lung: I. Intermittent exposures |
| |
| Authors: | Mohammad G. Mustafa Nabil M. Elsayed Fredrick M. von Dohlen Christopher M. Hassett Edward M. Postlethwait Christine L. Quinn Judith A. Graham Donald E. Gardner |
| |
| Affiliation: | 1. Division of Environmental and Occupational Health Sciences, School of Public Health, University of California, Los Angeles, California 90024 USA;2. Division of Pulmonary Disease, Department of Medicine, University of California, Los Angeles, California 90024 USA;3. Health Effects Research Laboratory, U.S. Environmental Protection Agency, Research Triangle Park, North Carolina, USA;4. Northrop Services Incorporated, Environmental Sciences, Research Triangle Park, North Carolina, USA |
| |
| Abstract: | Swiss Webster mice were exposed to either 4.8 ppm (9024 μg/m3) nitrogen dioxide (NO2), 0.45 ppm (882 μg/m3) ozone (O3), or their combination intermittently (8 hr daily) for 7 days, and the effects were studied in the lung by a series of physical and biochemical parameters, including lung weight, DNA and protein contents, oxygen consumption, sulfhydryl metabolism, and activities of NADPH generating enzymes. The results show that exposure to NO2 caused relatively smaller changes than O3, and that the effect of each gas alone under the conditions of exposure was not significant for most of the parameters tested. However, when the two gases were combined, the exposure caused changes that were greater and significant. Statistical analysis of the data shows that the effects of combined exposure were more than additive, i.e., they might be synergistic. The observations suggest that intermittent exposure to NO2 or O3 alone at the concentration used may not cause significant alterations in lung metabolism, but when the two gases are combined the alterations may become significant. |
| |
| Keywords: | To whom correspondence should be addressed. |
| 本文献已被 ScienceDirect 等数据库收录！ |
|
