被动吸烟与浸润性宫颈癌发病的研究——2010年复旦妇产科医院宫颈癌发病相关风险因素的Logistic回归分析

目的:了解与浸润性宫颈癌发病相关的风险因素,探讨被动吸烟与宫颈癌发病的相关性。方法:采用随机、对照的研究方法,对2010复旦大学附属妇产科医院新诊断的125例宫颈癌患者及对照组进行一对一地问卷调查,运用χ2检验、t检验,前进法似然比检验进行单因素分析,然后将筛选出的与宫颈癌发病相关的因素,纳入Logistic回归模型进行多因素分析。结果:Logistic回归分析结果显示,近10年内是否被动吸烟、被动吸烟的持续时间、接触强度是浸润性宫颈癌发病的高危因素(OR 2.592,95%CI 1.172～5.732),10年前被动吸烟与宫颈癌的发生无明显联系。另外,分娩次数也是宫颈癌的高危因素,家庭收入和年龄是发病的保护因素。结论:近10年内是否被动吸烟及接触时间、强度是浸润性宫颈癌发病相关危险因素。吸烟有害自己和他人的生命健康。

Second hand smoking and the risk of cervical cancer:a study of Logistic regression models from Obstetrics and Gynecology Hospital of Fudan University

Objective: To investigate the association between second hand smoking(SHS)and cervical cancer(CC).Methods:Information on risk factors of CC and lifetime history of SHS was obtained by personal interviews.Variables were compared using analysis of covariance.Associations were assessed using conditional logistic regression models to obtain estimates of OR and CI.Results:The meta-analysis indicated an increase risk of CC in participants with SHS during the past 10 years(OR 2.592,95% CI 1.172～5.732).A strong relationship was also observed between duration or strength of SHS in the time setting.No association was found for exposure to SHS 10 years ago or during childhood.Conclusion:A positive association between CC and SHS status in recent 10 years is confirmed.