175例子宫内膜异位症患者血清CA125水平的回顾性分析

目的:分析子宫内膜异位症患者合并子宫内膜息肉的情况,探讨血清CA125水平与痛经、内异症rAFS分期、病灶部位的相关性,为临床上更好地解读CA125水平提供依据。方法:回顾性分析2010年1月至12月我院术中或术后病理诊断为子宫内膜异位症的175例患者的临床资料。结果:(1)20.0%的子宫内膜异位症患者合并子宫内膜息肉;(2)36.6%的内异症患者有中、重度痛经,痛经程度与血清CA125水平无相关性;(3)Ⅰ期、Ⅱ期、Ⅲ期、Ⅳ期内异症患者的平均CA125水平分别为21.5U/ml、28.4U/ml、38.6U/ml、57.1U/ml,Ⅲ～Ⅳ期内异症患者血清CA125水平高于Ⅰ～Ⅱ期患者(P<0.05);(4)腹膜型、混合型、卵巢型内异症患者血清CA125的阳性率分别为21.4%、63.0%和67.4%,混合型、卵巢型内异症患者血清CA125阳性率显著高于腹膜型(P<0.001)。结论:血清CA125水平不能作为内异症合并子宫内膜息肉的预测指标;血清CA125水平可用于辅助鉴别内异症的分期和病灶部位,但是CA125对于内异症的早期诊断缺乏敏感性。

A retrospect analysis of the levels of serum CA125 in 175 patients with endometriosis

Objective:To analysis the rate of endometrial polyps in endometriosis patients,and to investigate the relationship between serum CA125 level in endometriosis patients and symptoms(such as dysmenorrhea),rAFS stage,lesion sites for better interpretation of CA125 clinically.Methods :We collect clinical data of 175 patients surgically and pathologically diagnosised with endometriosis in our hospital in 2010.Results:(1)The incidence rate of endometrial polyps in endometriosis patients was 20.0%.(2)36.6% of patients with endometriosis presented with moderate to severe dysmenorrhea,and serum CA125 level was not correlated with dysmenorrhea degree.(3)The average levels of serum CA125 inⅠ~Ⅳ rAFS stage endometriosis patients were 21.5U/ml,28.4U/ml,38.6U/ml and 57.1U/ml,respectively.The serum CA125 levels in Ⅲ~Ⅳ stage endometriosis patients was higher than that of the Ⅰ~Ⅱ stage patients(P<0.05).(4)The positive rates of serum CA125 in peritoneum endometriosis,ovarian endomitriosis and mix lesions were 21.4%,63.0% and 67.4%,respectively.Serum CA125 level in patients with ovarian lesions was higher than that of the patients with peritoneum lesions(P<0.001).Conclusions:Serum CA125 level couldn’t be used to distinguish endometriosis patients with endometrial polyps.Serum CA125 level could be used to discriminate endometriosis stages and lesion sites,but lack of sensitivity in early detection of endometriosis.