Contemporary treatment approaches for metastatic colorectal cancer driven by BRAF V600 mutations |
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Authors: | Ozkan Kanat Hulya Ertas Burcu Caner |
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Affiliation: | Ozkan Kanat, Department of Medical Oncology, Acıbadem Bursa Hospital, Bursa 16059, TurkeyHulya Ertas, Department of Medical Oncology, Bursa City Hospital, Bursa 16059, TurkeyBurcu Caner, Department of Medical Oncoloy, Balıkesir Ataturk City Hospital, Bursa 16059, Turkey |
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Abstract: | The treatment of metastatic colorectal cancer (mCRC) harboring BRAF V600 mutations is challenging. These tumors are often refractory to standard treatment. Therefore, the patients may exhibit rapid clinical deterioration, depriving them of the chance to receive salvage therapy. In newly diagnosed patients with good performance status, the administration of an intensive chemotherapy regimen like FOLFOXIRI (5-fluorouracil, leucovorin, oxaliplatin, and irinotecan) along with the antiangiogenic agent bevacizumab can modify this aggressive behavior of the disease and improve patient clinical outcomes. The recently published results of the BEACON (Binimetinib, Encorafenib, and Cetuximab Combined to Treat BRAF-Mutant Colorectal Cancer) study demonstrated that a combination therapy consisting of BRAF, epidermal growth factor receptor, and mitogen-activated protein kinase kinase inhibitors could be a useful second-or third-line alternative. This review summarizes the current treatment strategies for BRAF-mutant mCRC. |
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Keywords: | BRAF mutation V600 mutations Metastatic colorectal cancer Targeted therapies |
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| 点击此处可从《World journal of gastrointestinal oncology》浏览原始摘要信息 |
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