中性粒细胞/淋巴细胞比值联合平均血小板体积对急性STEMI患者PCI术后发生院内主要不良心血管事件的预测价值

背景　中性粒细胞/淋巴细胞比值（NLR）、平均血小板体积（MPV）均为新型的炎性反应标志物，可用来预测急性ST段抬高型心肌梗死（STEMI）患者的预后，但目前国内外鲜有研究探讨NLR联合MPV在预测STEMI患者预后方面的临床价值。目的　探讨NLR联合MPV对急性STEMI患者急诊行经皮冠状动脉介入（PCI）术后发生院内主要不良心血管事件（MACE）的预测价值。方法　连续选取2015年10月-2018年9月于石河子大学医学院第一附属医院明确诊断为STEMI并急诊行PCI的患者516例。依据患者急诊入院时外周血NLR、MPV的中位数将其分为低NLR且低MPV组（NLR≤2.51且MPV≤10.70 fl，n=135）、低NLR且高MPV组（NLR≤2.51且MPV>10.70 fl，n=123）、高NLR且低MPV组（NLR>2.51且MPV≤10.70 fl，n=137）、高NLR且高MPV组（NLR>2.51且MPV>10.70 fl，n=121）。依据全球急性冠脉综合征注册评分（GRACE评分）将其分为高危组（GRACE评分>140分，212例）、中危组（108分

Predictive Value of Neutrophil-to-lymphocyte Ratio Combined with Mean Platelet Volume for Nosocomial Major Adverse Cardiovascular Events in Patients with Acute STEMI after PCI

Background　Neutrophil-to-lymphocyte ratio （NLR） and mean platelet volume （MPV） are novel inflammatory response markers that can be used to predict the prognosis of patients with acute ST-segment elevation myocardial infarction （STEMI）.However，there are few studies exploring the clinical value of NLR combined with MPV in predicting the prognosis of STEMI patients.Objective　To investigate the predictive value of NLR combined with MPV in the occurrence of nosocomial major adverse cardiovascular events （MACE） after emergency percutaneous coronary intervention （PCI） in patients with acute STEMI.Methods　A total of 516 consecutive patients diagnosed as STEMI with emergency PCI in the First Affiliated Hospital of the Medical College，Shihezi University from October 2015 to September 2018 were selected.According to the median peripheral blood NLR and MPV on emergency admission，our cohort was divided into low NLR combined with low MPV group（NLR≤2.51 and MPV≤10.70 fl，n=135），low NLR and high MPV group（NLR≤2.51 and MPV>10.70 fl，n=123），high NLR combined with low MPV group（NLR>2.51 and MPV≤10.70 fl，n=137），high NLR combined with high MPV group（NLR>2.51 and MPV>10.70 fl，n=121）.Our cohort was divided into high-risk group（GRACE score>140 points，n=212），medium-risk group （108