中国汉族2型糖尿病人群体质量指数与血脂谱在糖尿病肾脏病中的交互作用

目的：探讨中国汉族2型糖尿病人群体质量指数（BMI）与血脂谱在糖尿病肾脏病（DKD）中的交互作用。方法：收集住院2型糖尿病患者647例，包括283例DKD患者以及364例非DKD的患者。采用二分类logistic回归分析血脂谱与DKD的相关性以及BMI与血脂谱的交互作用。结果：TG（OR=1.446，95%CI：1.076～1.942，P=0.014）、nonHDL-C（OR=1.961，95%CI：1.011～3.804，P=0.046）、nonHDL-C/HDL-C（OR=1.804，95%CI：1.134～2.869，P=0.013）、TC/HDL-C（OR=2.293，95%CI：1.234～4.260，P=0.009）、TG/HDL-C（OR=1.345，95%CI：1.057～1.712，P=0.016）均与DKD显著相关（OR针对各指标的自然对数计算）。BMI与TG、nonHDL-C/HDL-C、TC/HDL-C、TG/HDL-C之间的交互作用具有显著统计学意义（P值分别为0.036、0.035、0.034、0.016）。结论：中国汉族人群血浆TG、nonHDL-C、nonHDL-C/HDL-C、TC/HDL-C、TG/HDL-C均与DKD独立相关。BMI与TG、nonHDL-C/HDL-C、TC/HDL-C、TG/HDL-C之间存在交互作用。

Interaction between BMI and lipid profile in diabetic kidney disease in Chinese Han population with type 2 diabetes

Objective: To explore the interaction between BMI and lipid profile in diabetic kidney disease (DKD) in Chinese Han population with type 2 diabetes. Methods: We recruited 647 unrelated Han Chinese participants in this study, including 283 DKD patients and 364 non-DKD patients. Binary logistic regression was applied to analyze the association between lipid profile and DKD, and the interaction between BMI and lipid profile. Results: TG (OR=1.446, 95%CI: 1.076-1.942, P=0.014), nonHDL-C (OR=1.961, 95%CI: 1.011-3.804, P=0.046), nonHDL-C/HDL-C (OR=1.804, 95%CI: 1.134-2.869, P=0.013), TC/HDL-C (OR=2.293, 95%CI: 1.234-4.260, P=0.009), TG/HDL-C (OR=1.345, 95%CI: 1.057-1.712, P=0.016) were all significantly associated with DKD, ORs were calculated for the logarithmically transformed indexes. Significant interactions between BMI and TG, nonHDL-C/HDL-C, TC/HDL-C, TG/HDL-C were detected (P values equal to 0.036, 0.035, 0.034, 0.016, respectively). Conclusion: It is indicated that TG, nonHDL-C, nonHDL-C/HDL-C, TC/HDL-C, TG/HDL-C are significant risk factors for DKD in Chinese patients with type 2 diabetes. BMI modulated the association between lipid profile and DKD in this population.