水分去除的方法及其在药物合成中的应用

化学药合成过程中水分残留不利于反应的进行,还影响药物及制剂的稳定性、理化性质、溶出及药理作用等,因此水分几乎是大多数药物合成中的必测项目,通过有效除水严格控制反应体系中水分的含量至关重要。本文综述了水分的存在形式,常见除水剂和脱水剂的种类、作用原理与除水能力,以及在药物合成的应用,为药物合成反应中水分的去除提供参考。

Water Removal Methods and Application in Drug Synthesis

The residual water in raw materials and reaction system is not conducive to the synthesis of chemical drugs,and water content in bulk drugs and pharmaceutical preparations affects the stability,physical and chemical properties,dissolution and pharmacological effects.Therefore,residual water is almost a must-test item in the synthesis,and it is important to strictly control the water content in the reaction system by effective water removal methods.To provide some references for water removal in drug synthesis,this paper reviews the existence forms of water,common dewatering agents and dehydrating agents as well as their action principles and abilities of removing water.The applications of water removal in the synthesis of chemical drugs are briefly introduced.