基于ROC曲线的非亲缘造血干细胞捐献志愿者筛选标准

目的：基于ROC曲线分析方法探讨非亲缘造血干细胞捐献志愿者筛选标准。方法：采用问卷调查法收集温州市2007年至2018年间共40名成功捐献造血干细胞志愿者以及166名尚未完成捐献的入库志愿者信息，构建捐献认知、捐献意愿、捐献态度及三种得分联合检验的ROC曲线。结果：综合了捐献认知、捐献意愿及捐献态度的联合筛选方法ROC曲线下面积为0.87（95%CI：0.81～0.93），灵敏度为70.00%，特异度为90.96%，一致率为86.89%，Youden指数为0.61。结论：增强入库志愿者对非亲缘造血干细胞捐献的认知程度，提高入库志愿者的捐献意愿与态度，有利于提高志愿者的捐献可能性，降低悔捐率。

ROC curve-based study of the screening criteria for the unrelated hematopoietic stem cell donors

Objective: To determine the criteria for screening the unrelated hematopoietic stem cell donors based on the receiver operating characteristic curve (ROC curve). Methods: A questionnaire survey was conducted between 2007 and 2018 in Wenzhou City to collect information from 40 donors who donated hematopoietic stem cells and 166 potential donors in order to construct a ROC curve between donation cognition, donation willingness and donation attitude. Results: A joint screening method integrating the degree of donation cognition, donation willingness and donation attitude were used. The area under the ROC curve was 0.87 (95%CI: 0.81-0.93), with sensitivity being 70.00% and specificity 90.96%. The consistent rate was 86.89% and the Youden index was 0.61. Conclusion: To promote the possibility of donation and reduce the refusal rate, it is helpful to enhance the awareness of unrelated hematopoietic stem cell donors, while increasing their willingness and attitude towards hematopoietic stem cell donation.