冻干重组人脑利钠肽急诊治疗急性心力衰竭患者的效果

目的观察冻干重组人脑利钠肽急诊治疗急性心力衰竭患者的效果。方法选取菏泽市中医医院收治的104例急性心力衰竭患者作为研究对象,按治疗方式分为观察组(n=52)和对照组(n=52),对照组给予常规治疗,观察组在对照组的基础上给予冻干重组人脑利钠肽治疗,比较两组治疗前后各项心功能指标水平、血压、血浆脑钠肽(brain natriuretic peptide,BNP)、尿量及不良反应发生率。结果治疗后,观察组左室舒张末期内径、心率、左室射血分数以及二尖瓣舒张期E峰和A峰的比值(E/A)均明显优于对照组,差异均有统计学意义(P<0.05);治疗后,观察组尿量、收缩压、舒张压及血浆BNP水平均明显优于对照组,差异均有统计学意义(P<0.05);观察组治疗有效率为92.31%,明显高于对照组的50.00%,差异有统计学意义(P<0.05);观察组不良反应发生率为5.77%,明显低于对照组的23.08%,差异有统计学意义(P<0.05)。结论在常规治疗基础上采用冻干重组人脑利钠肽急诊治疗急性心力衰竭患者,可提高治疗有效率、改善心功能,降低不良反应发生率的效果优于常规治疗效果。

Effects of lyophilized recombinant human brain natriuretic peptide in emergency treatment of acute heart failure

Objective To observe effects of lyophilized recombinant human brain natriuretic peptide in emergency treatment of acute heart failure.Methods 104 patients with acute heart failure admitted to Heze Hospital of Traditional Chinese Medicine were selected as the research subjects,and were divided into an observation group(n=52)and a control group(n=52)according to the treatment method.The control group was given conventional anti-heart failure treatment,while the observation group was given lyophilized recombinant human brain natriuretic peptide on the basis of that of the control group.The levels of cardiac function indexes,blood pressure,plasma natriuretic peptide(BNP)and urine volume before and after the treatment,and incidence of adverse reactions were compared between the two groups.Results After the treatment,the left ventricular end diastolic diameter(LVEDD),heart rate,left ventricular ejection fraction(LVEF),and the ratio of the E and A peaks of the mitral valve diastole(E/A)in the observation group were significantly better than those in the control group,and the differences were statistically significant(P<0.05).After the treatment,the urine volume,systolic blood pressure,diastolic blood pressure,and plasma BNP level in the observation group were significantly better than those in the control group,and the differences were statistically significant(P<0.05).The effective rate in the observation group was 92.31%,which was significantly higher than 50.00%in the control group,and the difference was statistically significant(P<0.05).Further,the incidence of adverse reactions in the observation group was 5.77%,which was significantly lower than 23.08%in the control group,and the difference was statistically significant(P<0.05).Conclusions For the patients with acute heart failure,the application of lyophilized recombinant human brain natriuretic peptide based on the conventional anti-heart failure treatment can improve the treatment efficacy,improve the cardiac function,and reduce the incidence of adverse reactions,as compared with the conventional anti-heart failure treatment alone.