糖化血红蛋白测定在糖尿病诊断中的应用价值

目的探讨糖化血红蛋白(HbA1c)测定在糖尿病诊断中的应用价值。方法选择180例糖尿病患者作为观察组,另选择110例健康体检人员作为对照组。比较两组HbA1c、空腹血糖(FPG)及餐后2 h血糖(2 h PBG)水平及HbA1c、FPG、糖耐量试验(OGTT)检测糖尿病的特异度、灵敏度及阳性预测率。结果观察组HbA1c(8.45±1.39)%、FPG(6.21±1.59)mmol/L和2 h PBG(12.81±1.56)mmol/L均显著高于对照组的(4.59±1.29)%、(4.34±1.75)mmol/L、(6.89±1.34)mmol/L,差异有统计学意义(P<0.05)。Hb A1c、FPG检测糖尿病的特异度、阳性预测率均高于OGTT,HbA1c、OGTT检测糖尿病的灵敏度均高于FPG检测,差异有统计学意义(P<0.05)。结论HbA1c在糖尿病监控并发症、辅助治疗及诊断病情进展情况等方面具有重要的临床意义。

Application value of glycated hemoglobin in the diagnosis of diabetes mellitus

Objective To discuss the application value of glycated hemoglobin(HbA1 c)in the diagnosis of diabetes mellitus.Methods There were 180 patients with diabetes mellitus selected as the observation group,and another 110 healthy medical examiners as the control group.The levels of HbA1 c,fasting plasma glucose(FPG)and 2 h postprandial blood glucose(2 h PBG)were compared between the two groups.The specificity,sensitivity,and positive predictive rate of HbA1 c,FPG,and oral glucose tolerance test(OGTT)in the detection of diabetes mellitus were compared.Results HbA1 c(8.45±1.39)%,FPG(6.21±1.59)mmol/L and 2 h PBG(12.81±1.56)mmol/L of the observation group were significantly higher than those of the control group(4.59±1.29)%,(4.34±1.75)mmol/L and(6.89±1.34)mmol/L,and the difference was statistically significant(P<0.05).The specificity and positive predictive rate of HbA1 c and FPG in detecting diabetes mellitus were higher than that of OGTT,and the sensitivity of HbA1 c and OGTT in detecting diabetes mellitus was higher than that of FPG.The difference was statistically significant(P<0.05).Conclusion HbA1 c has important clinical significance in monitoring complications,auxiliary treatment and progression of diabetes mellitus.