Tourette综合征患儿症状严重程度与静息态功能磁共振脑低频振幅的关系

目的：分析Tourette综合征患儿症状严重程度与静息态功能磁共振脑低频振幅（ALFF）的关 系。方法：选取台州市第一人民医院2017年2月至2018年4月所收治20例首发Tourette综合征患儿，均接 受静息态功能磁共振扫描检查，分别在不同频段对脑ALFF值进行计算，探讨症状严重程度与脑ALFF值的相 关性。结果：左额上回眶部、右额中回、左额中回眶部的症状严重程度评分与脑ALFF值表现为正相关（ P ＜ 0.05）；左距状沟、右距状沟及其周围皮质的症状严重程度评分与脑ALFF值表现为负相关（ P ＜0.05）。结论： Tourette综合征患儿的症状严重程度与特定区域脑功能活动异常存在显著相关性。

The relationship between the amplitude of low-frequency fluctuation of resting functional magnetic resonance imaging under resting state and the severity degree of Tourette syndrome in children

Objective: To analyze the relationship between the amplitude of low-frequency fluctuation (ALFF) of resting functional magnetic resonance imaging under resting state and the severity degree of Tourette syndrome in children. Methods: 20 first-episode children with Tourette syndrome, admitted by the First People’s Hospital of Taizhou from February 2017 to April 2018, were recruited in the study, and all the patients were examined by fMRI. The ALFF of brain was respectively calculated in different frequency bands, and the relationship between the severity of symptoms and the ALFF was discussed that. Results: It was shown that a positive correlation between the score of symptom severity in orbital part of left superior forehead gyrus, right-to-middle frontalis orbital, left middle frontalis orbital region and the ALFF (P<0.05), and a negative correlation between the score of symptom severity in left distal sulcus, right distal sulcus, peripheral cortex and the ALFF (P<0.05). Conclusion: There is a significant correlation between the severity of symptoms in children with Tourette syndrome in resting state and abnormal brain function at regions.