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| 抑癌基因p16和p53在原发性胆囊癌中的表达及其相关性的初步研究 | |
| 引用本文： | 张东,冯德元,王平,邹赛英,何泽生. 抑癌基因p16和p53在原发性胆囊癌中的表达及其相关性的初步研究[J]. 中国普外基础与临床杂志, 2000, 7(2): 85-86 |
| 作者姓名： | 张东 冯德元 王平 邹赛英 何泽生 |
| 作者单位： | 1. 兰州军区乌鲁木齐总医院普外科,乌鲁木齐,830000 2. 兰州军区乌鲁木齐总医院病理科,乌鲁木齐,830000 3. 第四军医大学唐都医院,西安,710038 |
| 摘 要： | 目的 探讨ｐ１６和ｐ５３蛋白在胆囊癌发生、发展中的作用及其相关性。方法 应用免疫组化法对４０例胆囊癌组织中ｐ１６和ｐ５３蛋白的表达情况进行检测。结果 ｐ１６和５３蛋白的表达与胆囊癌的组织学分化，淋巴结转移以及预后相关；ｐ１６蛋白的表达还与临床分期有关。结论 ｐ１６蛋白的失表达是发生是胆囊癌发展的晚期阶段，认为ｐ１６和ｐ５３蛋白的表达有助于原发性胆囊癌的分化及其预后的判断。 |
| 关 键 词： | 原发性胆囊癌 p16基因 p53基因 基因表达 |
| 修稿时间： | 1999-03-01 |
EXPRESSION AND ASSOCIATION OF P16 AND P53 PROTEIN IN GALLBLADDER CARCINOMA |
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| Abstract: | Objective To study the association and the effect of the expression of p16 and p53 protein on the occurence and development of gallbladder carcinoma. Methods The expression of p16 and p53 protein were detected in 40 cases of gallbladder carcinoma with immunohistochemical method. Results The expressions of p16 and p53 protein were closely correlated to the tumor pathological grade, lymph mode metastasis and prognosis. p16 protein was correlated to the Nevin classifications. Conclusion The results indicate that the low expression rate of p16 protein occurred in the advanced stage of gallbladder carcinoma. The expression of p16 and p53 protein are helpful in judging the malignant degree and prognosis of primary gallbladder cancer. |
| Keywords: | Primary gallbladder carcinoma p16 protein p53 protein Immunohistochemistry |
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