Amniotic fluid levels of substance P. |
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| Authors: | J S Sanfilippo J J Botti R A Wild C O Osuamkpe |
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| Affiliation: | Department of Obstetrics and Gynecology, University of Louisville School of Medicine, Kentucky 40292. |
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| Abstract: | The presence of substance P (SP) in the amniotic fluid (AF) from 88 obstetric patients was determined with a radioimmunoassay. AF was collected from each patient in EDTA-coated tubes. Cross-reactivity of anti-SP antibody with methionine, met-enkephalin, leu-enkephalin, beta-endorphin, eledoisen and physalemin was less than 1%. The SP levels during the midtrimester were not significantly lower than those of late gestation. Data on the late-gestation group were evaluated further as per the clinical problem. The only statistically significant finding was between the diabetics with fetal maturity and the non-diabetic group. This preliminary study identified the presence of SP in AF in mid and late gestation. |
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