| 黄芪多糖硫酸酯的合成及其抗病毒活性研究 |
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| 引用本文： | 冯秀梅,陈邦银,张汉萍.黄芪多糖硫酸酯的合成及其抗病毒活性研究[J].中国药科大学学报,2002,33(2):68-70. |
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| 作者姓名： | 冯秀梅 陈邦银 张汉萍 |
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| 作者单位： | 华中科技大学同济医学院,武汉,430030 |
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| 摘 要： | 目的：制备黄芪多糖（PAM）硫酸酯，寻找具有优良抗病毒活性的物质。方法：将纯化得到的PAM，用硫酸化试剂氯磺酸－吡啶合成PAM硫酸酯（PAMS），采用体外抗病毒试验测定了PAMS对I型单纯疱疹病毒HSV－1的活怀。结果：制备了PAMS，在抑制HSV－1活性的试验中给药组与对照组（阿昔洛韦，ACV）之间有非常显著的差异。结论：PAMS有很强的抑制I型单纯疱疹病毒的活性，在相同浓度下，优于ACV。
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| 关 键 词： | 多糖硫酸酯 合成 体外 抗病毒 黄芪 |
| 文章编号： | 1000-5048(2002)02-0146-03 |
| 修稿时间： | 2001年9月11日 |
Synthesis and Antiviral Activity of Astragalus mongholicus Polysaccharide Sulfate |
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| Feng Xiu Mei,CHEN Bang Ying,ZHANG Han Ping Tongji Medical College,Huazhong University of Science and Technology,Wuhan,China.Synthesis and Antiviral Activity of Astragalus mongholicus Polysaccharide Sulfate[J].Journal of China Pharmaceutical University,2002,33(2):68-70. |
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| Authors: | Feng Xiu Mei CHEN Bang Ying ZHANG Han Ping Tongji Medical College Huazhong University of Science and Technology Wuhan China |
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| Institution: | Feng Xiu Mei,CHEN Bang Ying,ZHANG Han Ping Tongji Medical College,Huazhong University of Science and Technology,Wuhan 430030,China |
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| Abstract: | AIM The purpose is to prepare \%Astragalus mongholicus\% Bunge polysaccharide sulfate (PAMS), and to search for the substance with high antivirus activity. METHODS PAM was obtained by reaction of purified \%Astragalus mongholicus\% Bunge polysaccharide (PAM) with chlorosulfonic acid pyridine. The activity of PAMS was determinated by antiviral study \%in vitro\% on HSV 1. RESULTS There was very significant difference between the activities of PAMS and control acyclovir(ACV )on HSV 1. CONCLUSION PAM has shown higher activity on HSV 1 than that of ACV at the same concentration. |
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| Keywords: | Polysaccharide sulfate Synthesis Antiviral study \%In vitro\% \%Astragalus mongholicus\% |
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