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Primary malignant hemangiopericytoma of the breast: Report of a case
Authors:Nobuo Kanazawa  Atsushi Ono  Gaku Nitou  Ei Ueno  Masachika Fujiwara  Hiroshi Kamma  Naotaka Izumiya  Katashi Fukao
Affiliation:(1) Department of Surgery, Institute of Clinical Medicine, University of Tsukuba, 1-1-1 Tennoudai, 305-8575 Tsukuba Ibaraki, Japan;(2) Department of Pathology, Institute of Basic Sciences, University of Tsukuba, 1-1-1 Tennoudai, 305-8575 Tsukuba Ibaraki, Japan;(3) Department of Surgery, Mito Chuou Hospital, 1-15-1 Yanagimachi, 310-0817 Mito, Ibaraki, Japan;(4) Department of Clinical Pathology, Tokyo Metropolitan Geriatric Hospital, 35-2 Sakaemachi, Itabashi-ku, 173-0034 Tokyo, Japan;(5) Department of Surgery, Tokyo Metropolitan Geriatric Hospital, 35-2 Sakaemachi, Itabashi-ku, 173-0034 Tokyo, Japan
Abstract:A 70-year-old woman presented with a huge tumor in her left breast, which had rapidly increased in size causing cutaneous erosion. She underwent a simple mastectomy, at which time the tumor was found to be an encapsulated multilocular cystic lesion containing dark fluid. Histological examination disclosed the characteristic features of malignant hemangiopericytoma, including the perivascular lamellar growth of atypical mesenchymal cells with vimentin-positive cytoplasm. Multiple irregular vascular luminal formation was also conspicuous. The characteristics of this lesion are discussed together with a review of the previous literature on this unusual neoplasm.
Keywords:hemangiopericytoma  breast  immunohistochemistry  electron microscopy
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