The separated enantiomers of 2''-deoxy-3''-thiacytidine (BCH 189) both inhibit human immunodeficiency virus replication in vitro. |
| |
| Authors: | J A Coates N Cammack H J Jenkinson I M Mutton B A Pearson R Storer J M Cameron C R Penn |
| |
| Affiliation: | Department of Virology, Glaxo Group Research Ltd., Greenford, Middlesex, United Kingdom. |
| |
| Abstract: | Racemic 2'-deoxy-3'-thiacytidine (BCH 189) is a dideoxycytidine analog having a sulfur atom in place of the 3' carbon. The enantiomers of BCH 189 have been resolved and found to be equipotent in antiviral activity against human immunodeficiency virus types 1 and 2. However, the (-)-enantiomer (3TC) is considerably less cytotoxic than the (+)-enantiomer. |
| |
| Keywords: | |
|
|
