参芪扶正注射液对乳腺癌患者免疫功能的影响

目的 从细胞及分子水平探讨参芪扶正注射液对乳腺癌患者免疫功能损害的修复作用及机制。

Effect of Shenqi Fuzheng Injection on Repairing the Immune Function in Patients with Breast Cancer

Objective To investigate the effect and mechanism of Shenqi Fuzheng Injection （SFI） in repairing immune function of organism at cellular and molecular levels. Methods Seventy-seven patients with pathologically confirmed diagnosis of breast cancer were assigned to three groups, the 22 patients in group A received surgical operation only; the 26 in group B were treated with surgical operation and chemotherapy; and to the 29 in group C, both chemotherapy and SFI were given after surgical operation. Besides, a group D with 22 patients with benign tumor was set up for control. The protein expressions of CD83, CD80 and CD86 in all patients＇ tumor tissue and axiliary lymph node were detected by flow cytometry before and after treatment. Results Levels of CD83, CD80 and CD86 in both tumor tissue and lymph node of cancer patients were significantly lower than those in the control （ P〈0. 05） ; and those in group B were significantly lower than in group A （ P 〈 0.05, P 〈0.01 ） ; but no significant difference was found in comparing the corresponding indices between group A and group C （ P 〉 0.05）. Conclusion The immune function of tumor patients could be impaired by tumor and chemotherapy definitely, and SFI could give aid to the repairing of immunity by way of participating in the activation of dendritic cells and the up regulation of co- imulus molecules.