卡托普利对野百合碱诱发肺动脉高压的影响

目的探讨卡托普利(CPT)对野百合碱(MCT)诱发大鼠慢性炎性肺动脉高压的影响.方法将33只雄性Wister大鼠随机分为正常对照组、肺动脉高压模型组、CPT治疗组,每组11只.予MCT(50 mg/kg)复制大鼠肺动脉高压模型后,分别给CPT组及模型组大鼠连续灌胃CPT25 mg/(kg·d)或等量生理盐水21 d,采用改良右心导管术测定肺血流动力学参数,以非平衡法测定静脉血浆内皮素-1(ET-1)水平;处死大鼠后,称量肺湿重(wW)、右心室自由壁(RV)和左心室加室间隔(LV S)重,计算右心肥厚指数(RV/LV S).结果CPT能明显降低肺动脉高压模型大鼠的平均肺动脉压、wW、RV/LV S及血浆ET-1水平(P＜0.05,或P＜0.01).结论长期使用CPT能有效降低MCT所致肺动脉高压,改善心功能,其作用机制可能与显著降低血浆ET-1水平有关.

Effect of captopril on monocrotaline - induced pulmonary hypertension

Objective:To investigate the effect of captopril on monocrotaline-induced pulmonary hypertension in rats. Methods:Adult male Waister rats were given a single dose of monocrotaline(50 mg/kg) to induce the mold of pulmoanry hypertension.33 cases were randmonly divided into normal control group,mold group and captopril treatment group( n =11).Then treated with gastric infusion of normal saline,captopril respectively for 21 days. The parameter of pulmonary hemodynamics was monitored by Gould 3 400 polygrph system through the cannulation of polyvinyl tube. Right ventricle and left ventricle added with interventricular septum weight ratio,the lung wet weight were measured. The level of plasma endothetin-1 was determined by the method of nonequilibrium.Results: Captopril significantly inhibited the progression of pulmonary artery pressure( P <0.01).It decreased the right heart index, and reduced the lung wet weight and the level of plasma endothelin-1 ( P <0.05,or P <0,01 ).Conclusions:Captopril is able to reduce the pulmonary hypertension and improve the heart function. Its mechanisms may be related to reducing the level of plasma endothelin-1.