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| 盐酸拓扑替康的晶型与稳定性研究 | |
| 引用本文： | 陈民辉,杨宇,相秉仁,陈瑞拼. 盐酸拓扑替康的晶型与稳定性研究[J]. 中国生化药物杂志, 2005, 26(5): 279-281 |
| 作者姓名： | 陈民辉 杨宇 相秉仁 陈瑞拼 |
| 作者单位： | 1. 江苏省药品检验所,江苏,南京,210008 2. 中国药科大学,江苏,南京,210009 3. 南京中医药大学,药学2001级,江苏,南京,210029 |
| 摘 要： | 目的解析不同晶型盐酸拓扑替康理化性质变化以及稳定性。方法采用X射线衍射、热分析、红外分光光度法、高效液相色谱法。结果发现4种晶型的存在,4种晶型的熔点、X射线衍射图、红外吸收光谱图均有差异,其稳定性也存在差异。结论不同晶型的盐酸拓扑替康理化性质有差异,稳定性也存在差异,以B晶型最稳定。 |
| 关 键 词： | 盐酸拓扑替康 X射线衍射 热分析 红外 多晶型 稳定性 |
| 文章编号： | 1005-1678（2005）05-0279-03 |
| 收稿时间： | 2005-04-24 |
| 修稿时间： | 2005-06-06 |
Studies on the polymorph of topotecan hydrochloride and its stability |
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| CHEN Min-hui,YANG Yu,XIANG Bing-ren,CHEN Rui-pin. Studies on the polymorph of topotecan hydrochloride and its stability[J]. Chinese Journal of Biochemical Pharmaceutics, 2005, 26(5): 279-281 | |
| Authors: | CHEN Min-hui YANG Yu XIANG Bing-ren CHEN Rui-pin |
| Affiliation: | 1. Jiangsu Provincial Institute for Drug Control, Nanjing 210008, China; 2. China Pharmaceutical University, Nanjing 210009, China ; 3. Nanjing University of Traditional Chinese Medicine, Nanjing 210009, China |
| Abstract: | Purpose To find out the alteration of physico-chemical indexes on polymorphous crystalline form of topotecan hydrochloride, and its stability. Methods Usind X-ray power diffraction, TGA, DSC, IR and HPLC. Results Four crystal forms were found, four crystals had different melting point, X-ray power diffraction and infrared spectrum. Its stability was different too. Conclusion the physico-chemical indexes on polymorphous crystalline form were different, and B crystalline form was stable. |
| Keywords: | topotecan hydrochloride X-ray power diffraction thermal analysis infrared spectrum polymorph crystalline stability |
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