Comparison of ICD shock rates in Japanese and non‐Japanese patients in the PainFree SST study |
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| Authors: | Takashi Kurita MD PhD Kenji Ando MD Marehiko Ueda MD PhD Satoshi Shizuta MD Hideo Okamura MD PhD Naoki Matsumoto MD PhD Bart Gerritse PhD Dedra H. Fagan PhD Edward J. Schloss MD Albert Meijer MD Angelo Auricchio MD PhD Laurence D. Sterns MD Ken Okumura MD PhD |
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| Affiliation: | 1. Cardiology, Kindai University School of Medicine, Osaka, Japan;2. Department of Cardiology, Kokura Memorial Hospital, Fukuoka, Japan;3. Department of Cardiology, Eastern Chiba Medical Center, Chiba, Japan;4. Department of Cardiovascular Medicine, Kyoto University Graduate School of Medicine, Kyoto, Japan;5. Department of Cardiovascular Medicine, National Hospital Organization Wakayama Hospital, Wakayama, Japan;6. Pharmacology, St. Marianna University School of Medicine, Kanagawa, Japan;7. Medtronic Bakken Research Center, Maastricht, Netherlands;8. Medtronic plc, Mounds View, MN, USA;9. The Christ Hospital, Cincinnati, OH, USA;10. Catharina Ziekenhuis, Eindhoven, Netherlands;11. Fondazione Cardiocentro Ticino, Lugano, Switzerland;12. Vancouver Island Arrhythmia Clinic, Victoria, BC, Canada;13. Division of Cardiology, Saiseikai Kumamoto Hospital Cardiovascular Center, Kumamoto, Japan |
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| Abstract: | Background The PainFree Smart Shock Technology (SST) study showed a low implantable cardioverter‐defibrillator (ICD) inappropriate shock rate. However, the majority of patients were from Western countries with patient characteristics different from those in Japan. ICD shock rates using the novel SST algorithms in Japanese patients are still unknown. Methods All 2,770 patients in the PainFree SST study (Japan [JPN]: N = 181, other geographies [OJPN]: N = 2,589) were included in this analysis. Results Japanese patients had higher average left ventricular ejection fraction (P < 0.0001), higher prevalence of secondary prevention indications (P < 0.0001), nonischemic cardiomyopathy (P < 0.0001), and permanent atrial fibrillation (P < 0.0001). The appropriate shock rate at 12 months was not different between JPN and OJPN: 6.4% and 6.3%, respectively (P = 0.95). The inappropriate shock rate at 12 months was significantly higher in Japanese patients (2.9% vs 1.7%, P = 0.017). However, after propensity score matching to adjust for the difference in baseline characteristics, the difference in inappropriate shock rate was not statistically significant (P = 0.51). Conclusions There was no difference in the appropriate shock rate between Japan and other geographies. The inappropriate shock rate in Japan was low, although it was slightly higher compared to other geographies due to baseline characteristics, including a higher prevalence of permanent AF. There was not a statistically significant difference after adjusting for baseline characteristics. |
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| Keywords: | atrial fibrillation cardiac resynchronization therapy heart failure implantable cardioverter‐defibrillator inappropriate shock |
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