Test-specific analgesia elicited by kindled seizures in rats

Analgesia following kindled seizures in rats was studied using a test thought to measure pain integration at 3 levels of the CNS. Seizures caused an elevation of the threshold at which tail shocks elicited multiple squeaks, without affecting single squeak or tail withdrawal thresholds. Opioid involvement was indicated by naloxone's partial blockade of this effect.