| 视黄醇结合蛋白4与新诊断2型糖尿病合并非酒精性脂肪肝的关系研究 |
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| 引用本文： | 桑谊荃,马向华,倪 娟,谢 媛,李晓娜,俞 岭.视黄醇结合蛋白4与新诊断2型糖尿病合并非酒精性脂肪肝的关系研究[J].南京医科大学学报,2013(5):646-650. |
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| 作者姓名： | 桑谊荃 马向华 倪 娟 谢 媛 李晓娜 俞 岭 |
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| 作者单位： | 南京医科大学第一附属医院内分泌科,江苏 南京 210029;南京医科大学第一附属医院内分泌科,江苏 南京 210029;南京医科大学第一附属医院内分泌科,江苏 南京 210029;南京医科大学第一附属医院内分泌科,江苏 南京 210029;南京医科大学第一附属医院内分泌科,江苏 南京 210029;南京医科大学第一附属医院内分泌科,江苏 南京 210029 |
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| 基金项目： | 江苏省中医局项目(LZ11080) |
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| 摘 要： | 目的:探讨新诊断的2型糖尿病(type 2 diabetes mellitus,T2DM)合并非酒精性脂肪肝(nonalcoholic fatty liver disease,NAFLD)的代谢特征及与视黄醇结合蛋白4(retinol binding protein 4,RBP4)的关系?方法:收集新诊断的T2DM住院患者216例,根据是否合并NAFLD分为T2DM伴有NAFLD组144例和T2DM不伴NAFLD组72例?测量两组患者血压?体质指数(body mass index,BMI)?血脂总胆固醇(total cholesterol,TC)?甘油三酯(triglyceride,TG)?高密度脂蛋白胆固醇(high density lipoprotein cholesterol,HDL-C)?低密度脂蛋白胆固醇(low density lipoprotein cholestorol,LDL-C)?脂蛋白a(lipoprotein a,Lp-a)]?空腹血糖(fasting blood glucose,FBG)?空腹胰岛素(fasting insulin,FINS)?糖化血红蛋白(HbA1c)?血尿酸(uric acid,UA)?肝功能γ-谷氨酰转肽酶(γ-glutamyl transpeptidase,γ-GGT)?丙氨酸转氨酶(alanine transarninase,ALT)?天门冬氨酸转氨酶(aspartate transarninase,AST)]及RBP4,比较上述指标在两组间有无差异,并对相关指标做Logistic回归或Pearson相关分析?结果:新诊断的T2DM伴有NAFLD患者的BMI?收缩压?舒张压均高于T2DM不伴NAFLD组,较正年龄?性别?BMI后,T2DM伴NAFLD患者的TG?TC?FINS?胰岛素抵抗指数?γ-GGT?ALT?UA?RBP4显著高于T2DM不伴NAFLD组(P < 0.05)?2组FBG?HbA1c?HDL-C?LDL-C?Lp-a?AST在较正年龄?性别?BMI后差异无统计学意义(P > 0.05)?Logistic回归分析发现RBP4?BMI?ALT是新诊断的T2DM合并NAFLD的独立危险因素?T2DM合并NAFLD组的RBP4与胰岛素抵抗指数?HbA1c?FINS?γ-GGT?UA显著相关(P < 0.05)?结论:新诊断的T2DM伴有NAFLD较不伴NAFLD患者存在明显的胰岛素抵抗,并与代谢综合征组分(肥胖?高血压?高脂血症?高尿酸血症)相伴发生;RBP4及BMI?ALT在预测T2DM合并NAFLD风险方面有重要临床价值?
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| 关 键 词： | 2型糖尿病 非酒精性脂肪肝 视黄醇结合蛋白4 |
| 收稿时间： | 2012/12/7 0:00:00 |
The correlation between retinol binding protein 4 and nonalcoholic fatty liver disease in newly-diagnosed type 2 diabetes mellitus |
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| Sang Yiquan,Ma Xianghu,Ni Juan,Xie Yuan,Li Xiaona and Yu Ling.The correlation between retinol binding protein 4 and nonalcoholic fatty liver disease in newly-diagnosed type 2 diabetes mellitus[J].Acta Universitatis Medicinalis Nanjing,2013(5):646-650. |
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| Authors: | Sang Yiquan Ma Xianghu Ni Juan Xie Yuan Li Xiaona and Yu Ling |
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| Institution: | Department of Endocrinology,the First Affiliated Hospital of NJMU,Nanjing 210029,China;Department of Endocrinology,the First Affiliated Hospital of NJMU,Nanjing 210029,China;Department of Endocrinology,the First Affiliated Hospital of NJMU,Nanjing 210029,China;Department of Endocrinology,the First Affiliated Hospital of NJMU,Nanjing 210029,China;Department of Endocrinology,the First Affiliated Hospital of NJMU,Nanjing 210029,China;Department of Endocrinology,the First Affiliated Hospital of NJMU,Nanjing 210029,China |
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| Abstract: | |
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| Keywords: | type 2 diabetes mellitus nonalcoholic fatty liver disease retinol binding protein 4 |
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