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| 结核病患者氧氟沙星的群体药代动力学 | |
| 作者姓名： | M.Zhu J.J.Stambaugh S.E.Berning A.E.Bulpitt E.S.Hollender M.Narita D.Ashkin C.A.Peloquin 马玙 |
| 作者单位： | Department of Medicine，National Jewish Medical and Research Center，Denver，Colorado Drug Metabolism and Pharmacokinetics，Schering-Plough Research Institute，Kenilworth，New Jersey，AG Holley State Hospital，Lantana，Florida，Department of Medicine，National Jewish Medical and Research Center，Denver，Colorado School of Pharmacy，University of Colorado，Denver，Colorado，Department of Medicine，National Jewish Medical and Research Center，Denver，Colorado，AG Holley State Hospital，Lantana，Florida，AG Holley State Hospital，Lantana，Florida School of Pharmacy，University of Colorado，Denver，Colorado Division of Pulmonary and Critical Care Medicine，University of Miami School of Medicine，Miami，Bureau of Tuberculosis and Refugee Health，Florida Department of Health，Miami，Florida，AG Holley State Hospital，Lantana，Florida School of Pharmacy，University of Colorado，Denver，Colorado Division of Pulmonary and Critical Care Medicine，University of Miami School of Medicine，Miami，Bureau of Tuberculosis and Refugee Health，Florida Department of Health，Miami，Florida，Department of Medicine，National Jewish Medical and Research Center，Denver，Colorado School of Pharmacy，University of Colorado，Denver，Colorado School of Medicine，University of Colorado，Denver，Colorado，USA |
| 摘 要： | 背景:美国两所结核病医院。 目的:测定口服多种剂量氧氟沙星后的群体药代动力学(PK)。 设计:共73例结核病患者参加本研究,其中一部分患者接受多种剂量的氧氟沙星。根据药敏结果,同时服用其它药物。收集10小时以上的血清样本经高压液相色谱仪测定,采用群体方法分析浓度-时间数据。 结果:氧氟沙星浓度随增加的口服剂量呈线形上升。29％患者至少有一次吸收延缓。氧氟沙星清除随肾功能下降和年龄增加而降低。患者对较高剂量耐受良好,且可最大限度提高血药峰值浓度与最低抑菌浓度之比值(Cmax:MIC)。 结论:氧氟沙星群体药代动力学参数与以往报告结果相似。较高剂量可具有良好的药代动力学,有利于结核病的治疗。 |
| 关 键 词： | 氧氟沙星 结核病 药代动力学 |
| 本文献已被 CNKI 等数据库收录！ | |