精氨酸对阻塞性黄疸机体NK细胞活性及淋巴细胞DNA合成能力的影响

阻塞性黄疸患者围手术期易感性明显高于非黄疸者,其发病原因尚不完全清楚。本文研究了阻塞性黄疸大鼠脾脏NK细胞活性的变化及脾脏性淋巴细胞DNA合成能力的改变,同时观察了精氨酸对阻塞性黄疸大鼠的免疫调节作用;并将精氨酸应用于临床,观察其对阻塞性黄疸患者外周血淋巴细胞DNA合成能力的影响。结果显示:胆管结扎大鼠脾脏NK细胞活性明显下降,脾脏淋巴细胞DNA合成能力明显受抑,而应用精氮酸治疗的胆管结扎大鼠NK细胞活性明显高于单纯胆管结扎组,淋巴细胞DNA合成能力也明显强于单纯胆管结扎组。临床研究结果显示:给阻塞性黄疸病人应用精氨酸治疗后,外周血淋巴细胞DNA合成能力也明显增强。因此,精氨酸作为一种免疫刺激剂,有可能成为临床上改善阻塞性黄疸病人免疫功能有价值的药物之一。

IMMUNOREGULATORY EFFECTS OF ARGININE ON RATS WITH OBSTRUCTIVE JAUNDICE

The patients with obstructive jaundice have a higher susceptibility to infection in peri-operative period. The reason for this is unclear. This artical reports that changes of NK activity and splenocyte DNA synthesis capacity in rats with obstructive jaundice and we also observed the immunoregulatory effects of Arginine on rats with obstructive jaundice. The results show that NK activity was significantly decreased, DNA synthesis capacity clearly depressed in rats with obstructive jaundice. Arginine could markedly increase NK activity and splenocyte DNA synthesis capcity in rats with obstructive jaundice. Clinical study also proved that arginine could enhance markedly lymphocyte DNA synthesis in patients with obstructive jaundice. So arginine, as a immunostimulating agent, mignt be a valuable drug to improve immune function of patients with obstructive jaundice.