Immunomodulating and antistress activity of ecdysterone and turkesterone under immobilization-induced stress conditions in mice |
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| Authors: | G. A. Shakhmurova V. N. Syrov Z. A. Khushbaktova |
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| Affiliation: | 1.Nizami Tashkent State Pedagogical University,Tashkent,Uzbekistan;2.Yunusov Institute of the Chemistry of Plant Substances,Academy of Sciences of the Republic of Uzbekistan,Tashkent,Uzbekistan |
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| Abstract: | The phytoecdysteroids ecdysterone and turkesterone isolated from Rhaponticum integrifolium and Ajuga turkestanica herbs, respectively, increase the adaptation capacity of mice under immobilization-induced stress conditions. These compounds prevent involution of the thymicolymphatic system, decrease trophic disorders in gastric mucosa, prevent an increase in the weight of adrenal glands and a decrease in them of the content of ascorbic acid and cholesterol (to a much greater degree than does T-activin), and stimulate immunogenesis in animals with experimental immune deficiency developed on the background of immobilization-induced stress. |
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