| Cox17基因拷贝数在高原习服中的变化规律 |
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| 引用本文： | 罗勇军,李素芝,黄学文,王宇亮,陈丽,陈有,刘福玉,周其全,高钰琪. Cox17基因拷贝数在高原习服中的变化规律[J]. 西南国防医药, 2011, 21(3): 233-235. DOI: 10.3969/j.issn.1004-0188.2011.03.001 |
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| 作者姓名： | 罗勇军 李素芝 黄学文 王宇亮 陈丽 陈有 刘福玉 周其全 高钰琪 |
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| 作者单位： | 1. 第三军医大学高原军事医学系高原疾病学教研室,高原医学教育部重点实验室,全军高原生理与高原病研究重点实验室,重庆,400038
2. 西藏军区总医院高山病科 |
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| 摘 要： | 目的探讨Cox17拷贝数在高原习服中的变化规律。方法分别取年龄、职业等相匹配的世居藏族组（n=20）、移居汉族组（n=20）和平原汉族组（n=18）受试者静脉血2 ml/人,提取DNA,通过定量PCR方法（染料法）检测Cox17基因的相对拷贝数。结果移居汉族的Cox17基因拷贝数最低,平原汉族的拷贝数较多,世居藏族的Cox17基因拷贝数最高。结论 Cox17基因的拷贝数变化可能是高原习服的机制之一。
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| 关 键 词： | Cox17 拷贝数 高原 习服 |
Change of Cox17 copy number in migrant Han people during altitude acclimatization |
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| Luo Yongjun,Li Suzhi,Huang Xuewen,Wang Yuliang,Chen Li,Chen You,Liu Fuyu,Zhou Qiquan,Gao Yuqi. Change of Cox17 copy number in migrant Han people during altitude acclimatization[J]. Medical Journal of National Defending forces in Southwest China, 2011, 21(3): 233-235. DOI: 10.3969/j.issn.1004-0188.2011.03.001 |
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| Authors: | Luo Yongjun Li Suzhi Huang Xuewen Wang Yuliang Chen Li Chen You Liu Fuyu Zhou Qiquan Gao Yuqi |
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| Affiliation: | Luo Yongjun1,Li Suzhi2,Huang Xuewen2,Wang Yuliang2,Chen Li1,Chen You2,Liu Fuyu1,Zhou Qiquan1,Gao Yuqi1 1.Department of High Altitude Disease,College of High Altitude Military Medicine/Key Laboratory of High Altitude Medicine of Education Ministry/Key Laboratory of High Altitude Physiology and High Altitude Disease of PLA,Third Military Medical University,Chongqing,400038,China,2.Department of Mountain Sickness,General Hospital of Tibet Military Command,Lhasa,Tibet,850003 |
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| Abstract: | Objective To explore the change of Cox17 copy number in immigrants during altitude acclimatization.Methods 2 ml of venous blood samples from 20 native Tibetans,20 migrant Han people and 18 plain Han people with matched age,profession,etc.were collected for DNA extraction.Then Cox17 copy numbers were detected by real-time PCR(dye method).Results The copy numbers of Cox17 from the lowest to highest were migrant Han people,plain Han people and native Tibetan in order.Conclusion The change of Cox17 copy number ... |
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| Keywords: | Cox17 |
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